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Project Description

P02 - Lipases and the Control of Energy Balance, Lipis Signaling, and Lipotoxicity

Rudolf Zechner & Guenter Hämmerle

Principal Hypothesis and Objectives

Based on previous findings that the ATGL co-activator CGI-58 has additional, ATGL-independent functions in the liver, we propose to identify the biochemical nature of these activities and study their physiological consequences. Additionally, we hypothesize that the recently discovered cysteine-palmitoylation of ATGL, HSL, and CGI-58 affects their lipolytic function. We will test this hypothesis by exploring the regulation of the lipolytic pathway in response to enzyme and co-activator palmitoylation. Related to this objective, we will also address the question of how lipolysis affects the palmitoylation of the cellular proteome and the function of specific target proteins involved in lipid and energy metabolism.


Zechner         Haemmerle
Rudolf ZechneroooooooooooooooooooooGünter Hämmerle (Co-PI)

CV & Publication List R. Zechner in pdf format
CV & Publication List G. Hämmerle
in pdf format

University of Graz
Institute of Molecular Biosciences
Heinrichstr. 31, A-8010 Graz

email: vanessa.csitkovits@uni-graz.at

Other Research Grants

Project Title
Grant No.
ERC Advanced Grant: The Role of Lipolysis in the Pathogenesis of Cancer-associated Cachexia (Zechner)
European Research Council - 340896
TNT – Triglyceride Metabolism in Obesity and Cardiovascular Disease (Zechner)
Leducq Foundation
Role of CGI-58 in Epidermal Barrier Formation (Hämmerle)

FWF P24944

Doktoratskolleg (Ph.D. excellence program) Molecular Enzymology (Zechner)
FWF W901
Doktoratskolleg (Ph.D. excellence program) Metabolic and Cardiovascular Disease (Hämmerle)
FWF W1226
TNT – Triglyceride Metabolism in Obesity and Cardiovascular Disease (Zechner)
Leducq Foundation

updated 15.06.2016

Supported by the Austrian Science Fund

Project Management: Dr. Vanessa Csitkovits, University of Graz, Institute of Molecular Biosciences, Heinrichstrasse 31, A-8010 Graz, Austria