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Project Description

P08 - Role of Bile Acids in the Control of Hepatic Lipid Metabolism and Defense against Lipotoxicity: Focus on Crosstalk with Metabolic Lipases
Michael Trauner

Principal Hypothesis and Objectives

We hypothesize that metabolic lipases, and in particular adiponutrin (PNPLA3), play a critical role in the progression of fatty liver disease by determining hepatic fatty acid flux, partitioning and signaling. The objectives of this project are (1) to investigate the consequences of altered metabolic lipase action in the pathogenesis of hepatic lipotoxicity with subsequent hepatocellular injury, inflammation, fibrosis, and cancer; (2) to explore the role of bile acids, which are modulators of PNPLA3 and potentially counteract hepatic lipotoxicity, and (3) to evaluate the role of PNLPA3 in determining the metabolic response to fructose in human liver in vivo.


Michael Trauner

CV & Publication List M. Trauner in pdf format


Vienna General Hospital
Department of Medicine III
Division of Gastroenterology and Hepatology
Währinger Gürtel 18-20, A-1090 Vienna

email: michael.trauner@meduniwien.ac.at

Other Research Grants

Project Title
Grant No.
SFB Transmembrane Transporters in Health and Disease P17: Molecular Regulation of Hepatobiliary ABC Transporters in Cholestatic Liver Diseases FWF F3517
Unravelling the Pathogenetic Mechanisms of Fructose Consumption as Multiple hit in the Pathogenesis and Progression of Non-alcoholic Fatty Liver Disease (NAFLD) WWTF LS12-008
Doktoratskolleg (Ph.D. excellence program) Inflammation and Immunity
FWF W1212


  updated 07.06.2016               

Supported by the Austrian Science Fund

Project Management: Dr. Vanessa Csitkovits, University of Graz, Institute of Molecular Biosciences, Heinrichstrasse 31, A-8010 Graz, Austria