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Project Description

P15 - Sensing of Lipid Peroxidation Derived -epitopes by Macrophages and Innate Immunity
hristoph J. Binder

Principal Hypothesis and Objectives

MAA-epitopes are lipid peroxidation-derived danger signals that are sensed by macrophages and bound by the humoral innate immune defense protein FH. We hypothesize that MAA-epitopes represent effectors of lipotoxicity and that they are mediators of inflammation in various pathologies, including atherosclerosis. Thus, we aim to elucidate the consequences of defective lipolysis on innate immune responses in macrophages in vitro and murine models in vivo, and assess the contribution of MAA-epitopes to these responses. We will define the cellular responses of macrophages sensing MAA-epitopes, and the protective capacity of FH-mediated scavenging will be studied in murine atherosclerosis.

Christoph J. Binder                               

CV & Publication List C. Binder in pdf format

Medical University of Vienna
Department of Laboratory Medicine
Währinger Gürtel 18-20, 1090 Wien

CeMM - Center for Molecular Medicine of the Austrian Academy of Sciences

email: christoph.binder@meduniwien.ac.at

Other Research Grants

Project Title
Grant No.
Vaccination in Atherosclerosis
EU 603131-2
SFB - Cellular Mediators Linking Inflammation and Thrombosis
FWF F5402
DK - CCHD Cellular Communication in Health and Disease
FWF W1205

  updated 04.01.2017               

Supported by the Austrian Science Fund

Project Management: Julia Fröhlich, PhD, University of Graz, Institute of Molecular Biosciences, Heinrichstrasse 31, A-8010 Graz, Austria