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Project Description

P16 - Characterizing the Structures of Proteins Involved in Lipolysis - G0S2, A Novel Protein Inhibitor of ATGL
Monika Oberer

Principal Hypothesis and Objectives

Regulation of ATGL at the protein level is mediated by the proteins G0S2 and CGI-58, yet the underlying mechanisms are largely unknown. The inhibitor G0S2 has been reported to interfere in different biological processes and is predicted to be partly α-helical and partly unstructured. We hypothesize that the inherent flexibility in G0S2 is essential for interaction with different target proteins. The objectives of this work are to characterize the regions of G0S2 essential for ATGL regulation along with the corresponding 3D structures. The results will provide insights into how G0S2 exerts its biological function on ATGL. Overall, the outcome of this work will lead to a better understanding of this small, yet versatile and flexible protein.

Monika Oberer                               

CV & Publication List M. Oberer in pdf format


University of Graz
Institute of Molecular Biosciences
Humboldtstr. 50, A-8010 Graz

email: m.oberer@uni-graz.at

Other Research Grants

Project Title
Grant No.
Structural Characterization of Monoglyceride Lipases FWF P24857
Transatlantic Network on Triglycerides-Triglyceride Metabolism in Obesity and Cardiovascular Disease Foundation Leducq 12CVD04
Doktoratskolleg (Ph.D. excellence program) Molecular Enzymology
FWF W901
Unravelling the Secrets of the Lipolysom

  updated 18.03.2016               

Supported by the Austrian Science Fund

Project Management: Dr. Vanessa Csitkovits, University of Graz, Institute of Molecular Biosciences, Heinrichstrasse 31, A-8010 Graz, Austria