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Publications




Foto: cp pictures Austria, Schuchlautz



 

Publications 2017

Impact factor 2016 not yet available

Grond S, Radner FPW, Eichmann TO, Kolb D, Grabner GF, Wolinski H, Gruber R, Hofer P, Heier C, Schauer S, Rülicke T, Hoefler G, Schmuth M, Elias PM, Lass A, Zechner R, Haemmerle G. 2017. Skin Barrier Development Depends on CGI-58 Protein Expression During Late-Stage Keratinocyte Differentiation.J Invest Dermatol. 137(2):403-413. doi: 10.1016/j.jid.2016.09.025.

Kory N, Grond S, Kamat SS, Li Z, Krahmer N, Chitraju C, Zhou P, Fröhlich F, Semova I, Ejsing C, Zechner R, Cravatt BF, Farese RV Jr, Walther TC. 2017. Mice lacking lipid droplet-associated hydrolase, a gene linked to human prostate cancer, have normal cholesterol ester metabolism. J Lipid Res. 58(1):226-235. doi: 10.1194/jlr.M072538.

Arab JP, Karpen SJ, Dawson PA, Arrese M, Trauner M.2017. Bile acids and nonalcoholic fatty liver disease: Molecular insights and therapeutic perspectives.Hepatology.65(1):350-362. doi: 10.1002/hep.28709.

Bruschi FV, Claudel T, Tardelli M, Caligiuri A, Stulnig TM, Marra F, Trauner M. 2017. The PNPLA3 I148M variant modulates the fibrogenic phenotype of human hepatic stellate cells. Hepatology. doi: 10.1002/hep.29041. [Epub ahead of print]

Lelu S, Afadzi M, Berg S, Aslund AK, Torp SH, Sattler W, de L Davies C. 2017. Primary Porcine Brain Endothelial Cells as In Vitro Model to Study Effects of Ultrasound and Microbubbles on Blood-Brain Barrier Function. IEEE Trans Ultrason Ferroelectr Freq Control.64(1):281-290. doi: 10.1109/TUFFC.2016.2597004.

Mayerhofer R, Fröhlich EE, Reichmann F, Farzi A, Kogelnik N, Fröhlich E, Sattler W, Holzer P. 2017. Diverse action of lipoteichoic acid and lipopolysaccharide on neuroinflammation, blood-brain barrier disruption, and anxiety in mice. Brain Behav Immun. 60:174-187. doi: 10.1016/j.bbi.2016.10.011.

Publications 2016

Impact factor 2015 in parenthesis

Vujic N, Porter Abate J, Schlager S, David T, Kratky D, Koliwad SK. 2016.  Acyl-CoA:Diacylglycerol Acyltransferase 1 Expression Level in the Hematopoietic Compartment Impacts Inflammation in the Vascular Plaques of Atherosclerotic Mice     PLoS One. 11(5):e0156364. (3,057)

Pietrocola F, Pol J, Vacchelli E, Baracco EE, Levesque S, Castoldi F, Maiuri MC, Madeo F, Kroemer G. 2016.  Autophagy induction for the treatment of cancer. Autophagy. 12(10):1962-1964. (9,108)

Plastira I, Bernhart E, Goeritzer M, Reicher H, Kumble VB, Kogelnik N, Wintersperger A, Hammer A, Schlager S, Jandl K, Heinemann A, Kratky D, Malle E, Sattler W. 2016. 1-Oleyl-lysophosphatidic acid (LPA) promotes polarization of BV-2 and primary murine microglia towards an M1-like phenotype. J Neuroinflammation. 13(1):205. (4,667)

Papac-Milicevic N, Busch CJ, Binder CJ. 2016. Malondialdehyde Epitopes as Targets of Immunity and the Implications for Atherosclerosis. Adv Immunol. 2016; 131:1-59. (7,064)

Hendrikx T, Watzenböck ML, Walenbergh SM, Amir S, Gruber S, Kozma MO, Grabsch HI, Koek GH, Pierik MJ, Staufer K, Trauner M, Kalhan SC, Jonkers D, Hofker MH, Binder CJ, Shiri-Sverdlov R. 2016.  Low levels of IgM antibodies recognizing oxidation-specific epitopes are associated with human non-alcoholic fatty liver disease     BMC Med. 14(1):107. (8,005)

Gruber S, Hendrikx T, Tsiantoulas D, Ozsvar-Kozma M, Göderle L, Mallat Z, Witztum JL, Shiri-Sverdlov R, Nitschke L, Binder CJ. 2016. Sialic Acid-Binding Immunoglobulin-like Lectin G Promotes Atherosclerosis and Liver Inflammation by Suppressing the Protective Functions of B-1 Cells. Cell Rep. 14(10):2348-61. (7,870)

Gupta VK, Pech U, Bhukel A, Fulterer A, Ender A, Mauermann SF, Andlauer TF, Antwi-Adjei E, Beuschel C, Thriene K, Maglione M, Quentin C, Bushow R, Schwärzel M, Mielke T, Madeo F, Dengjel J, Fiala A, Sigrist SJ. 2016.  Spermidine Suppresses Age-Associated Memory Impairment by Preventing Adverse Increase of Presynaptic Active Zone Size and Release.     PLoS Biol. 14:e1002563. (8,668)

Huang J, Li L, Lian J, Schauer S, Vesely PW, Kratky D, Hoefler G, Lehner R. 2016. Tumor-Induced Hyperlipidemia Contributes to Tumor Growth. Cell Rep. 15(2):336-48. (7,870)

Lord CC, Ferguson D, Thomas G, Brown AL, Schugar RC, Burrows A, Gromovsky AD, Betters J, Neumann C, Sacks J, Marshall S, Watts R, Schweiger M, Lee RG, Crooke RM, Graham MJ, Lathia JD, Sakaguchi TF, Lehner R, Haemmerle G, Zechner R, Brown JM. 2016.  Regulation of Hepatic Triacylglycerol Metabolism by CGI-58 Does Not Require ATGL Co-activation. Cell Rep. 16(4):939-949. (7,870)

Binder CJ, Papac-Milicevic N, Witztum JL. 2016. Innate sensing of oxidation-specific epitopes in health and disease. Nat Rev Immunol. 16(8):485-97. Nat Rev Immunol (39,416)

López-Otín C, Galluzzi L, Freije JM, Madeo F, Kroemer G. 2016. Metabolic Control of Longevity. Cell. 166(4):802-21.     (28,710)

Vogl F, Humpolícková J, Amaro M, Koller D, Köfeler H, Zenzmaier E, Hof M, Hermetter A. 2016.  Role of protein kinase C δ in apoptotic signaling of oxidized phospholipids in RAW 264. Biochim Biophys Acta. 1861(4):320-30. (2,590)

Aschauer P, Rengachari S, Lichtenegger J, Schittmayer M, Das KM, Mayer N, Breinbauer R, Birner-Gruenberger R, Gruber CC, Zimmermann R, Gruber K, Oberer M. 2016. Crystal structure of the Saccharomyces cerevisiae monoglyceride lipase Yju3p     Biochim Biophys Acta. 1861(5):462-70. (2,590)

Sachdev V, Leopold C, Bauer R, Patankar JV, Iqbal J, Obrowsky S, Boverhof R, Doktorova M, Scheicher B, Goeritzer M, Kolb D, Turnbull AV, Zimmer A, Hoefler G, Hussain MM, Groen AK, Kratky D. 2016. Novel role of a triglyceride-synthesizing enzyme: DGAT1 at the crossroad between triglyceride and cholesterol metabolism. Biochim Biophys Acta. 1861(9 Pt A):1132-41. doi: 10.1016/j.bbalip.2016.06.014. (2,590)

Eisenberg T, Abdellatif M, Schroeder S, Primessnig U, Stekovic S, Pendl T, Harger A, Schipke J, Zimmermann A, Schmidt A, Tong M, Ruckenstuhl C, Dammbrueck C, Gross AS, Herbst V, Magnes C, Trausinger G, Narath S, Meinitzer A, Hu Z, Kirsch A, Eller K, Carmona-Gutierrez D, Büttner S, Pietrocola F, Knittelfelder O, Schrepfer E, Rockenfeller P, Simonini C, Rahn A, Horsch M, Moreth K, Beckers J, Fuchs H, Gailus-Durner V, Neff F, Janik D, Rathkolb B, Rozman J, de Angelis MH, Moustafa T, Haemmerle G, Mayr M, Willeit P, von Frieling-Salewsky M, Pieske B, Scorrano L, Pieber T, Pechlaner R, Willeit J, Sigrist SJ, Linke WA, Mühlfeld C, Sadoshima J, Dengjel J, Kiechl S, Kroemer G, Sedej S, Madeo F. 2016. Cardioprotection and lifespan extension by the natural polyamine spermidine. Nat Med. 22(12):1428-38. (30,357)

Mitchell SJ, Madrigal-Matute J, Scheibye-Knudsen M, Fang E, Aon M, González-Reyes JA, Cortassa S, Kaushik S, Gonzalez-Freire M, Patel B, Wahl D, Ali A, Calvo-Rubio M, Burón MI, Guiterrez V, Ward TM, Palacios HH, Cai H, Frederick DW, Hine C, Broeskamp F, Habering L, Dawson J, Beasley TM, Wan J, Ikeno Y, Hubbard G, Becker KG, Zhang Y, Bohr VA, Longo DL, Navas P, Ferrucci L, Sinclair DA, Cohen P, Egan JM, Mitchell JR, Baur JA, Allison DB, Anson RM, Villalba JM, Madeo F, Cuervo AM, Pearson KJ, Ingram DK, Bernier M, de Cabo R. 2016.  Effects of Sex, Strain, and Energy Intake on Hallmarks of Aging in Mice. Cell Metab. 23(6):1093-112. (17,303)

Vujic N, Schlager S, Eichmann TO, Madreiter-Sokolowski CT, Goeritzer M, Rainer S, Schauer S, Rosenberger A, Woelfler A, Doddapattar P, Zimmermann R, Hoefler G, Lass A, Graier WF, Radovic B, Kratky D.  2016. Monoglyceride lipase deficiency modulates endocannabinoid signaling and improves plaque stability in ApoE-knockout mice     Atherosclerosis. 244:9-21 (3,942)

Jeurissen ML, Walenbergh SM, Houben T, Gijbels MJ, Li J, Hendrikx T, Oligschlaeger Y, van Gorp PJ, Binder CJ, Donners MM, Shiri-Sverdlov R.2016.  Prevention of oxLDL uptake leads to decreased atherosclerosis in hematopoietic NPC1-deficient Ldlr-/- mice. Atherosclerosis. 255:59-65. (3,942)

Heier C, Taschler U, Radulovic M, Aschauer P, Eichmann TO, Grond S, Wolinski H, Oberer M, Zechner R, Kohlwein SD, Zimmermann R. 2016.  Monoacylglycerol lipases act as evolutionarily conserved regulators of non-oxidative ethanol metabolism. J Biol Chem. 291(22):11865-75. (4,258)

Grumet L, Eichmann TO, Taschler U, Zierler KA, Leopold C, Moustafa T, Radovic B, Romauch M, Yan C, Du H, Haemmerle G, Zechner R, Fickert P, Kratky D, Zimmermann R, Lass A. 2016. Lysosomal Acid Lipase Hydrolyzes Retinyl Ester and Affects Retinoid Turnover. J Biol Chem. 291(34):17977-17987. (4,258)

Chauhan N, Han GS, Somashekarappa N, Gable K, Dunn T, Kohlwein SD. 2016.  Regulation of Sphingolipid Biosynthesis by the Morphogenesis Checkpoint Kinase Swe1. J Biol Chem. 291(5):2524-34. (4,258)

Pietrocola F, Pol J, Vacchelli E, Rao S, Enot DP, Baracco EE, Levesque S, Castoldi F, Jacquelot N, Yamazaki T, Senovilla L, Marino G, Aranda F, Durand S, Sica V, Chery A, Lachkar S, Sigl V, Bloy N, Buque A, Falzoni S, Ryffel B, Apetoh L, Di Virgilio F, Madeo F, Maiuri MC, Zitvogel L, Levine B, Penninger JM, Kroemer G. 2016. Caloric Restriction Mimetics Enhance Anticancer Immunosurveillance. Cancer Cell. 30(1):147-60. (23,214)

Vinod M, Patankar JV, Sachdev V, Frank S, Graier WF, Kratky D, Kostner GM. 2016.  MiR-206 is Expressed in Pancreatic Islets and Regulates Glucokinase Activity. Am J Physiol Endocrinol Metab. 311(1):E175-85. (3,825)

Carmona-Gutierrez D, Hughes AL, Madeo F, Ruckenstuhl C. 2016. The crucial impact of lysosomes in aging and longevity     Ageing Res Rev. 32:2-12.    (7,526)

Mayer FJ, Binder CJ, Wagner OF, Schillinger M, Minar E, Mlekusch W, Tsiantoulas D, Georg G, Hoke M. 2016.  Combined Effects of Inflammatory Status and Carotid Atherosclerosis: A 12-Year Follow-Up Study. Stroke. 47(12):2952-58.    (5,787)

Radovic B, Vujic N, Leopold C, Schlager S, Goeritzer M, Patankar JV, Korbelius M, Kolb D, Reindl J, Wegscheider M, Tomin T, Birner-Gruenberger R, Schittayer M, Groschner L, Magnes C, Diwoky C, Frank S, Steyrer E, Du H, Graier WF, Madl T, Kratky D. 2016. Lysosomal acid lipase regulates VLDL synthesis and insulin sensitivity in mice. Diabetologia. 59(8):1743-52. (6,206)

Nusshold C, Ullen A, Kogelnik N, Bernhart E, Reicher H, Plastira I, Glasnov T, Zangger K, Rechberger G, Kollroser M, Fauler G, Wolinski H, Weksler BB, Romero IA, Kohlwein SD, Couraud PO, Malle E, Sattler W. 2016. Assessment of electrophile damage in a human brain endothelial cell line utilizing a clickable alkyne analog of 2-chlorohexadecanal. Free Radic Biol Med. 90:59-74. (5.780)

Busch CJ, Binder CJ. 2016. Malondialdehyde epitopes as mediators of sterile inflammation. Biochim Biophys Acta. 1862(4):398-406. doi: 10.1016/j.bbalip.2016.06.016.8 (2.509)

Al-Zoughbi W, Pichler M, Gorkiewicz G, Guertl-Lackner B, Haybaeck J, Jahn SW, Lackner C, Liegl-Atzwanger B, Popper H, Schauer S, Nusshold E, Kindt ASD, Trajanoski Z, Speicher MR, Haemmerle G, Zimmermann R, Zechner R, Vesely PW, Hoefler G. 2016. Loss of Adipose Triglyceride Lipase is associated with human cancer and induces mouse pulmonary neoplasia. Oncotarget. 7(23):33832-33840 (5,008)

Publications 2015

Impact factor 2014 in parenthesis

Rockenfeller P, Carmona-Gutierrez D, Pietrocola F, Kroemer G, Madeo F. 2015. Ethanolamine: A novel anti-aging agent. Mol Cell Oncol, 3(1):e1019023. (5.331)

Dražić T, Sachdev V, Leopold C, Patankar JV, Malnar M, Hećimović S, Levak-Frank S, Habuš I, Kratky D. 2015. Synthesis and evaluation of novel amide amino-β-lactam derivatives as cholesterol absorption inhibitors. Bioorg Med Chem, 23(10):2353-2359.

Out C, Patankar JV, Doktorova M, Boesjes M, Bos T, de Boer S, Havinga R, Wolters H, Boverhof R, van Dijk TH, Smoczek A, Bleich A, Sachdev V, Kratky D, Kuipers F, Verkade HJ, Groen AK. 2015. Gut microbiota inhibit Asbt-dependent intestinal bile acid reabsorption via Gata4. J Hepatol, 63(3):697-704.

Goeritzer M, Vujic N, Schlager S, Chandak PG, Korbelius M, Gottschalk B, Leopold C, Obrowsky S, Rainer S, Doddapattar P, Aflaki E, Wegscheider M, Sachdev V, Graier WF, Kolb D, Radovic B, Kratky D. 2015. Active autophagy but not lipophagy in macrophages with defective lipolysis. Biochim Biophys Acta, 1851(10):1304-131.

Niso-Santano M, Malik SA, Pietrocola F, Bravo-San Pedro JM, Mariño G, Cianfanelli V, Ben-Younès A, Troncoso R, Markaki M, Sica V, Izzo V, Chaba K, Bauvy C, Dupont N, Kepp O, Rockenfeller P, Wolinski H, Madeo F, Lavandero S, Codogno P, Harper F, Pierron G, Tavernarakis N, Cecconi F, Maiuri MC, Galluzzi L, Kroemer G. 2015. Unsaturated fatty acids induce non-canonical autophagy. EMBO J, 34(8):1025-1041.

Libiseller G, Dvorzak M, Kleb U, Gander E, Eisenberg T, Madeo F, Neumann S, Trausinger G, Sinner F, Pieber T, Magnes C. 2015. IPO: a tool for automated optimization of XCMS parameters. BMC Bioinformatics, 16:118.

Braun RJ, Sommer C, Leibiger C, Gentier RJ, Dumit VI, Paduch K, Eisenberg T, Habernig L, Trausinger G, Magnes C, Pieber T, Sinner F, Dengjel J, van Leeuwen FW, Kroemer G, Madeo F. 2015. Accumulation of Basic Amino Acids at Mitochondria Dictates the Cytotoxicity of Aberrant Ubiquitin. Cell Rep, pii: S2211-1247(15)00137-0.

Madeo F, Zimmermann A, Maiuri MC, and Kroemer G.2015. Essential role for autophagy in life span extension. J Clin Invest, 2015, 125(1): 85–93. (13.215)

Heier C, Radner FP, Moustafa T, Schreiber R, Grond S, Eichmann TO, Schweiger M, Schmidt A, Cerk IK, Oberer M, Theussl HC, Wojciechowski J, Penninger JM, Zimmermann R, Zechner R. 2015. G0/G1 Switch Gene 2 Regulates Cardiac Lipolysis. J Biol Chem, 290(43):26141-50. (4.573)

Schreiber R, Hofer P, Taschler U, Voshol PJ, Rechberger GN, Kotzbeck P, Jaeger D, Preiss-Landl K, Lord CC, Brown JM, Haemmerle G, Zimmermann R, Vidal-Puig A, Zechner R. 2015. Hypophagia and metabolic adaptations in mice with defective ATGL-mediated lipolysis cause resistance to HFD-induced obesity. Proc Natl Acad Sci U S A, 112(45):13850-5. (9.674)

Hofer P, Boeszoermenyi A, Jaeger D, Feiler U, Arthanari H, Mayer N, Zehender F, Rechberger G, Oberer M, Zimmermann R, Lass A, Haemmerle G, Breinbauer R, Zechner R, Preiss-Landl K. 2015. Fatty Acid-binding Proteins Interact with Comparative Gene Identification-58 Linking Lipolysis with Lipid Ligand Shuttling. J Biol Chem, 290(30):18438-53. (4.573)

Mueller M, Thorell A, Claudel T, Jha P, Koefeler H, Lackner C, Hoesel B, Fauler G, Stojakovic T, Einarsson C, Marschall HU, Trauner M. 2015. Ursodeoxycholic acid exerts farnesoid X receptor-antagonistic effects on bile acid and lipid metabolism in morbid obesity. J Hepatol, 62(6):1398-404. (11.336)

Eichmann TO, Grumet L, Taschler U, Hartler J, Heier C, Woblistin A, Pajed L, Kollroser M, Rechberger G, Thallinger GG, Zechner R, Haemmerle G, Zimmermann R, Lass A. 2015. ATGL and CGI-58 are lipid droplet proteins of the hepatic stellate cell line HSC-T6. J Lipid Res, 56(10):1972-84. (4.421)

Schweiger M, Zechner R. 2015. Breaking the Barrier-chaperone-mediated autophagy of perilipins regulates the lipolytic degradation of fat. Cell Metab, 22(1):60-1. (17.565)

Jaeger D, Schoiswohl G, Hofer P, Schreiber R, Schweiger M, Eichmann TO, Pollak NM, Poecher N, Grabner GF, Zierler KA, Eder S, Kolb D, Radner FP, Preiss-Landl K, Lass A, Zechner R, Kershaw EE, Haemmerle G. 2015. Fasting-induced G0/G1 switch gene 2 and FGF21 expression in the liver are under regulation of adipose tissue derived fatty acids. J Hepatol, 63(2):437-45. (11.336)

Zechner R. 2015. FAT FLUX: enzymes, regulators, and pathophysiology of intracellular lipolysis. EMBO Mol Med, 7(4):359-62. (8.665)

Pollak NM, Jaeger D, Kolleritsch S, Zimmermann R, Zechner R, Lass A, Haemmerle G. 2015. The interplay of protein kinase A and perilipin 5 regulates cardiac lipolysis. J Biol Chem, 290(3):1295-306. (4.573)

Schlager S, Goeritzer M, Jandl K, Frei R, Vujic N, Kolb D, Strohmaier H, Dorow J, Eichmann TO, Rosenberger A, Wölfler A, Lass A, Kershaw EE, Ceglarek U, Dichlberger A, Heinemann A, Kratky D. 2015. Adipose triglyceride lipase acts on neutrophil lipid droplets to regulate substrate availability for lipid mediator synthesis. J Leukoc Biol, 98(5):837-50. (4.289)

Nusshold C, Üllen A, Kogelnik N, Bernhart E, Reicher H, Plastira I, Glasnov T, Zangger K, Rechberger G, Kollroser M, Fauler G, Wolinski H, Weksler BB, Romero IA, Kohlwein SD, Couraud PO, Malle E, Sattler W. 2015. Assessment of electrophile damage in a human brain endothelial cell line utilizing a clickable alkyne analog of 2-chlorohexadecanal. Free Radic Biol Med,. pii: S0891-5849(15)01108-9. (5.736)

Bernhart E, Damm S, Wintersperger A, Nusshold C, Brunner AM, Plastira I, Rechberger G, Reicher H, Wadsack C, Zimmer A, Malle E, Sattler W. 2015. Interference with distinct steps of sphingolipid synthesis and signaling attenuates proliferation of U87MG glioma cells. Biochem Pharmacol, 96(2):119-30. (5.009)

Üllen A, Nusshold C, Glasnov T, Saf R, Cantillo D, Eibinger G, Reicher H, Fauler G, Bernhart E, Hallstrom S, Kogelnik N, Zangger K, Oliver Kappe C, Malle E, Sattler W. 2015. Covalent adduct formation between the plasmalogen-derived modification product 2-chlorohexadecanal and phloretin. Biochem Pharmacol, 93(4):470-81. (5.009)

Rockenfeller P, Koska M, Pietrocola F, Minois N, Knittelfelder O, Sica V, Franz J, Carmona-Gutierrez D, Kroemer G, Madeo F. 2015. Phosphatidylethanolamine positively regulates autophagy and longevity. Cell Death Differ, 22(3):499-508. (8.184)

Carmona-Gutierrez D, Zimmermann A, Madeo F. 2015. A molecular mechanism for lipophagy regulation in the liver. Hepatology, 61(6):1781-3. (11.055)

Tsiantoulas D, Sage AP, Mallat Z, Binder CJ. 2015. Targeting B cells in atherosclerosis: closing the gap from bench to bedside. Arterioscler Thromb Vasc Biol, 35(2):296-302. (6.008)

Tsiantoulas D, Perkmann T, Afonyushkin T, Mangold A, Prohaska TA, Papac-Milicevic N, Millischer V, Bartel C, Hörkkö S, Boulanger CM, Tsimikas S, Fischer MB, Witztum JL, Lang IM, Binder CJ. 2015. Circulating microparticles carry oxidation-specific epitopes and are recognized by natural IgM antibodies. J Lipid Res, 56(2):440-8. (4.421)

Sahu-Osen A, Montero-Moran G, Schittmayer M, Fritz K, Dinh A, Chang YF, McMahon D, Boeszoermenyi A, Cornaciu I, Russell D, Oberer M, Carman GM, Birner-Gruenberger R, Brasaemle DL. 2015. CGI-58/ABHD5 is phosphorylated on Ser239 by protein kinase A: control of subcellular localization. J Lipid Res, 56(1):109-21. (4.421)

Rengachari S, Aschauer P, Sturm C, Oberer M. 2015. Purification, crystallization and preliminary X-ray diffraction analysis of a soluble variant of the monoglyceride lipase Yju3p from the yeast Saccharomyces cerevisiae. Acta Crystallogr F Struct Biol Commun, 71(Pt 2):243-6. (0.527)

Boeszoermenyi A, Nagy HM, Arthanari H, Pillip CJ, Lindermuth H, Luna RE, Wagner G, Zechner R, Zangger K, Oberer M. 2015. Structure of a CGI-58 Motif Provides the Molecular Basis of Lipid Droplet Anchoring. J Biol Chem, 290(44):26361-72. (4.573)

Adeyo O, Oberer M, Ploug M, Fong LG, Young SG, Beigneux AP. 2015. Heterogeneity in the properties of mutant secreted lymphocyte antigen 6/urokinase receptor-related protein 1 (SLURP1) in Mal de Meleda. Br J Dermatol; 173(4):1066-9. (4.275)

 

Publications 2014

Impact factor 2012 in parenthesis

Zierler KA, Zechner R, Haemmerle G. 2014. Comparative gene identification-58/α/β hydrolase domain 5: more than just an adipose triglyceride lipase activator? Curr Opin Lipidol, 25(2):102-109. (5.839)

Schweiger M, Eichmann TO, Taschler U, Zimmermann R, Zechner R, Lass A. 2014. Measurement of lipolysis. Methods Enzymol, 538:171-193. (2.002)

Schreiber R, Zechner R. 2014. Lipolysis meets inflammation: arachidonic acid mobilization from fat. J Lipid Res, 55(12):2447-9. (4.386)

Brahma MK, Adam RC, Pollak NM, Jaeger D, Zierler KA, Pöcher N, Schreiber R, Romauch M, Moustafa T, Eder S, Ruelicke T, Preiss-Landl K, Lass A, Zechner R, Haemmerle G. 2014. Fibroblast growth factor 21 is induced upon cardiac stress and alters cardiac lipid homeostasis. J Lipid Res, 55(11):2229-41. (4.386)

Tsoli M, Schweiger M, Vanniasinghe AS, Painter A, Zechner R, Clarke S, Robertson G. 2014. Depletion of white adipose tissue in cancer cachexia syndrome is associated with inflammatory signaling and disrupted circadian regulation. PLoS One, 9(3):e92966. (3.730)

Weinert BT, Iesmantavicius V, Moustafa T, Schölz C, Wagner SA, Magnes C, Zechner R, Choudhary C. 2014. Acetylation dynamics and stoichiometry in Saccharomyces cerevisiae. Mol Syst Biol, 10:716. (11.340)

Grahn TH, Kaur R, Yin J, Schweiger M, Sharma VM, Lee MJ, Ido Y, Smas CM, Zechner R, Lass A, Puri V. 2014. Fat-specific Protein 27 (FSP27) interacts with ATGL to regulate lipolysis and insulin sensitivity in human adipocytes. J Biol Chem, 289(17):12029-12039. (4.651)

Schrammel A, Mussbacher M, Wolkart G, Stessel H, Pail K, Winkler S, Schweiger M, Haemmerle G, Al Zoughbi W, Hofler G, Lametschwandtner A, Zechner R, Mayer B. 2014. Endothelial dysfunction in adipose triglyceride lipase deficiency. Biochim Biophys Acta, 1841(6):906-917. (5.538)

Vinod M, Chennamsetty I, Colin S, Belloy L, De Paoli F, Schaider H, Graier WF, Frank S, Kratky D, Staels B, Chinetti-Gbaguidi G, Kostner GM. 2014. miR-206 controls LXRα expression and promotes LXR-mediated cholesterol efflux in macrophages. Biochim Biophys, 1841(6):827-35. (5.538)

Rossmann C, Windpassinger C, Brunner D, Kovacevic A, Schweighofer N, Malli R, Schuligoi R, Prokesch A, Kluve-Beckerman B, Graier WF, Kratky D, Sattler W, Malle E. 2014. Characterization of rat serum amyloid A4 (SAA4): a novel member of the SAA superfamily. Biochem Biophys Res Commun, 450(4):1643-9. (2.406)

Goeritzer M, Schlager S, Radovic B, Madreiter CT, Rainer S, Thomas G, Lord CC, Sacks J, Brown AL, Vujic N, Obrowsky S, Sachdev V, Kolb D, Chandak PG, Graier WF, Sattler W, Brown JM, Kratky D. 2015. Deletion of CGI-58 or adipose triglyceride lipase differently affects macrophage function and atherosclerosis. J Lipid Res, 55(12):2562-75. (4.386)

Chirackal Manavalan AP, Kober A, Metso J, Lang I, Becker T, Hasslitzer K, Zandl M, Fanaee-Danesh E, Pippal JB, Sachdev V, Kratky D, Stefulj J, Jauhiainen M, Panzenboeck U. 2014. Phospholipid transfer protein is expressed in cerebrovascular endothelial cells and involved in high density lipoprotein biogenesis and remodeling at the blood-brain barrier. J Biol Chem, 289(8):4683-4698. (4.651)

Röhrl C, Eigner K, Winter K, Korbelius M, Obrowsky S, Kratky D, Kovacs WJ, Stangl H. 2014. Endoplasmic reticulum stress impairs cholesterol efflux and synthesis in hepatic cells. J Lipid Res, 55(1):94-103. (4.386)

Kratky D, Obrowsky S, Kolb D, Radovic B. 2014. Pleiotropic regulation of mitochondrial function by adipose triglyceride lipase-mediated lipolysis. Biochimie, 96:106-112. (3.142)

Knittelfelder OL, Weberhofer BP, Eichmann TO, Kohlwein SD, Rechberger GN. 2014. A versatile ultra-high performance LC-MS methodfor lipid profiling. J Chromatogr B Analyt Technol Biomed Life Sci, 951-952:119-128. (2.487)

Hofbauer HF, Schopf FH,  Schleifer H, Knittelfelder OL, Pieber B, Rechberger GN, Wolinski H, Gaspar ML, Kapp OC, Stadlmann J, Mechtler K, Zenz A, Lohner K, Tehlivets O, Henry SA, Kohlwein SD. 2014. Regulation of Gene Expression through a Transcriptional Repressor that Senses Acyl-Chain Length in Membrane Phospholipids. Dev Cell, 29(6):729-739. (12.861)

Knittelfelder OL, Weberhofer BP, Eichmann TO, Kohlwein SD, Rechberger GN. 2014. A versatile ultra-high performance LC-MS method for lipid profiling. J Chromatogr B Analyt Technol Biomed Life Sci, 951-952:119-28. doi: 10.1016/j.jchromb.2014.01.011. (2.487)

van Zutphen T, Todde V, de Boer R, Kreim M, Hofbauer HF, Wolinski H, Veenhuis M, van der Klei IJ, Kohlwein SD. 2014. Lipid droplet autophagy in the yeast Saccharomyces cerevisiae. Mol Biol Cell, 25(2):290-301. (4.803)

Scherübel S, Koyani CN, Hallstr&oulm;m S, Lang P, Platzer D, Mächler H, Lohner K, Malle E, Zorn-Pauly K, Pelzmann B. 2014. If blocking potency of ivabradine is preserved under elevated endotoxin levels in human atrial myocytes. J Mol Cell Cardiol, 72C:64-73. (5.148)

Ghosh A, Birngruber T, Sattler W, Kroath T, Ratzer M, Sinner F, Pieber TR. 2014. Assessment of blood-brain barrier function and the neuroinflammatory response in the rat brain by using cerebral Open Flow Microperfusion (cOFM). PLoS One, 9(5):e98143. (3.730)

Koyani CN, Windischhofer W, Rossmann C, Jin G, Kickmaier S, Heinzel FR, Groschner K, Alavian-Ghavanini A, Sattler W, Malle E. 2014. 15-deoxy-Delta-PGJ promotes inflammation and apoptosis in cardiomyocytes via the DP2/MAPK/TNFalpha axis. Int J Cardiol, 173(3):472-480. (5.509)

Scharnagl H, Kleber ME, Genser B, Kickmaier S, Renner W, Weihrauch G, Grammer T, Rossmann C, Winkelmann BR, Boehm BO, Sattler W, März W, Malle E. 2014. Association of myeloperoxidase with total and cardiovascular mortality in individuals undergoing coronary angiography-The LURIC Study. Int J Cardiol,174(1):96-105. (5.509)

Bernhart E, Damm S, Heffeter P, Wintersperger A, Asslaber M, Frank S, Hammer A, Strohmaier H, Devaney T, Mrfka M, Eder H, Windpassinger C, Ireson CR, Mischel PS, Berger W, Sattler W. 2014. Silencing of protein kinase D2 induces glioma cell senescence via p53-dependent and -independent pathways. Neuro Oncol, 16 (7):933-945. (6.180)

Jha P, Knopf A, Koefeler H, Mueller M, Lackner C, Hoefler G, Claudel T, Trauner M. 2014. Role of adipose tissue in methionine-choline-deficient model of non-alcoholic steatohepatitis (NASH). Biochim Biophys Acta, 1842(7):959-970. (5.538)

Fuchs CD, Claudel T, Trauner M. 2014. Role of metabolic lipases and lipolytic metabolites in the pathogenesis of NAFLD. Trends Endocrinol Metab, 25(11):576-85.(9-392)

Schaap FG, Trauner M, Jansen PL. 2014. Bile acid receptors as targets for drug development. Nat Rev Gastroenterol Hepatol, 11(1):55-67. Review. (10.426)

Madeo F, Pietrocola F, Eisenberg T, Kroemer G. 2014. The search for anti-aging interventions: From elixirs to fasting regimens. Caloric restriction mimetics: towards a molecular definition. Nat Rev Drug Discov, 13(10):727-40. Review. (29.008)

Madeo F, Pietrocola F, Eisenberg T, Kroemer G. 2014. Caloric restriction mimetics: towards a molecular definition. Nat Rev Drug Discov, 13(10):727-40. (29.008)

Eisenberg T, Schroeder S, Andryushkova A, Pendl T, Küttner V, Bhukel A, Mariño G, Pietrocola F, Harger A, Zimmermann A, Moustafa T, Sprenger A, Jany E, Büttner S, Carmona-Gutierrez D, Ruckenstuhl C, Ring J, Reichelt W, Schimmel K, Leeb T, Moser C, Schatz S, Kamolz LP, Magnes C, Sinner F, Sedej S, Fröhlich KU, Juhasz G, Pieber TR, Dengjel J, Sigrist SJ, Kroemer G, Madeo F. 2014. Nucleocytosolic depletion of the energy metabolite acetyl-coenzyme a stimulates autophagy and prolongs lifespan. Cell Metab, 19(3):431-44. (14.619)

Eisenberg T, Schroeder S, Büttner S, Carmona-Gutierrez D, Pendl T, Andryushkova A, Marino G, Pietrocola F, Harger A, Zimmermann A, Magnes C, Sinner F, Sedej S,. Pieber TR, Dengjel J, Sigrist SJ, Kroemer G, Madeo F. 2014. A histone point mutation that switches on autophagy. Autophagy, 10(6):1143-1145. Review. (12.042)

Schroeder S, Pendl T, Zimmermann A, Eisenberg T, Carmona-Gutierrez D, Ruckenstuhl C, Mariño G, Petrocola F, Harger A, Magnes C, Sinner F, Pieber TR, Dengjel J, Sigrist SJ, Kroemer G and Madeo F. 2014. Acetyl-coenzyme A - a metabolic master regulator of autophagy and longevity. Autophagy, 10(7):1335-7. (12.042)

De Cabo R, Carmona-Gutierrez D, Bernier M, Hall MN, Madeo F. 2014. The search for anti-aging interventions: From elixirs to fasting regimens. Cell, 157(7):1515-26. (31.957)

Sigrist SJ, Carmona-Gutierrez D, Gupta VK, Bhukel A, Mertel S, Eisenberg T, Madeo F. 2014. Spermidine-triggered autophagy ameliorates memory during aging. Autophagy, 10(1):178-179. doi: 10.4161/auto.26918. (12.042)

Marino G, Pietrocola F, Eisenberg T, Kong Y, Malik SA, Andryushkova A, Schroeder S, Pendl T, Harger A, Niso-Santano M, Zamzami N, Scoazec M, Durand S, Enot DP, Fernández AF, Martins I, Kepp O, Senovilla L, Bauvy C, Morselli E, Vacchelli E, Bennetzen M, Magnes C, Sinner F, Pieber T, López-Otín C, Maiuri MC, Codogno P, Andersen JS, Hill JA, Madeo F, Kroemer G. 2014. Regulation of autophagy by cytosolic acetyl-coenzyme a. Mol Cell, 53(5):710-725. (15.280)

Magnes C, Fauland A, Gander E, Narath S, Ratzer M, Eisenberg T, Madeo F, Pieber T, Sinner F. 2014. Polyamines in biological samples: Rapid and robust quantification by solid-phase extraction online-coupled to liquid chromatography-tandem mass spectrometry. J Chromatogr A, 1331:44-51. (4.612)

Al-Zhoughbi W, Huang J, Paramasivan GS, Till H, Pichler M, Guertl-Lackner B, Hoefler G. 2014. Tumor macroenvironment and metabolism. Semin Oncol, 41(2):281-295. (4.327)

Tsiantoulas D, Diehl CJ, Witztum JL, Binder CJ. 2014. B Cells and Humoral Immunity in Atherosclerosis. Circ Res, 114(11):1743-1756. Review. (11.861)

Schuh C, Wimmer I, Hametner S, Haider L, Van Dam AM, Liblau RS, Smith KJ, Probert L, Binder CJ, Bauer J, Bradl M, Mahad D, Lassmann H. 2014. Oxidative tissue injury in multiple sclerosis is only partly reflected in experimental disease models. Acta Neuropathol, 128(2):247-66. (9.734)

Nagy HM, Paar M, Heier C, Moustafa T, Hofer P, Haemmerle G, Lass A, Zechner R, Oberer M, Zimmermann R. 2014. Adipose triglyceride lipase activity is inhibited by long-chain acyl-coenzyme A. Biochim Biophys Acta, 1841(4):588-594. (5.538)

Harper S, Gratton HE, Cornaciu I, Oberer M, Scott DJ, Emsley J, Dreveny I. 2014. Structure and catalytic regulatory function of ubiquitin specific protease 11 N-terminal and ubiquitin-like domains. Biochemistry, 53(18):2966-78. (3.377)

Steinkellner G, Gruber CC, Pavkov-Keller T, Binter A, Steiner K, Winkler C, Lyskowski A, Schwamberger O, Oberer M, Schwab H, Faber K, Macheroux P, Gruber K. 2014. Identification of promiscuous ene-reductase activity by mining structural databases using active site constellations. Nat Commun, 5:4150. (10.015)

Cerk IK, Salzburger B, Boeszoermenyi A, Heier C, Pillip C, Romauch M, Schweiger M, Cornaciu I, Lass A, Zimmermann R, Zechner R, Oberer M. 2014. A peptide derived from G0/G1 switch gene 2 acts as noncompetitive inhibitor of adipose triglyceride lipase. J Biol Chem, 289(47):32559-70. (4.651)

 

Publications 2013

Schrammel A, Mussbacher M, Winkler S, Haemmerle G, Stessel H, Wölkart G, Zechner R, Mayer B. 2013. Cardiac oxidative stress in a mouse model of neutral lipid storage disease. Biochim Biophys Acta, 1831(11):1600-1608. (5.538)

Young SG, Zechner R. 2013. Biochemistry and pathophysiology of intravascular and intracellular lipolysis. Genes Dev. 2013 Mar 1;27(5):459-484. Review. (12.444)

Currie E, Schulze A, Zechner R, Walther TC, Farese RV Jr. 2013. Cellular fatty acid metabolism and cancer. Cell Metab, 18(2):153-161. (14.619)

Pulinilkunnil T, Kienesberger PC, Nagendran J, Waller TJ, Young ME, Kershaw EE, Korbutt G, Haemmerle G, Zechner R, Dyck JR. 2013. Myocardial Adipose Triglyceride Lipase Overexpression Protects Diabetic Mice From the Development of Lipotoxic Cardiomyopathy. Diabetes, 62(5):1464-1477. (7.895)

Chitraju C, Trötzmüller M, Hartler J, Wolinski H, Thallinger GG, Haemmerle G, Zechner R, Zimmermann R, Köfeler HC, Spener F. 2013. The impact of genetic stress by ATGL deficiency on the lipidome of lipid droplets from murine hepatocytes. J Lipid Res, 54(8):2185-2194. (4.612)

Kienesberger PC, Pulinilkunnil T, Nagendran J, Young ME, Bogner-Strauss JG, Hackl H, Khadour R, Heydari E, Haemmerle G, Zechner R, Kershaw EE, Dyck JR. 2013. Early structural and metabolic cardiac remodelling in response to inducible adipose triglyceride lipase ablation. Cardiovasc Res, 99(3):442-451. (5.940)

Mayer N, Schweiger M, Romauch M, Grabner GF, Eichmann TO, Fuchs E, Ivkovic J, Heier C, Mrak I, Lass A, Höfler G, Fledelius C, Zechner R, Zimmermann R, Breinbauer R. 2013. Development of small-molecule inhibitors targeting adipose triglyceride lipase. Nat Chem Biol, 9(12):785-787. (12.948)

Zierler KA, Jaeger D, Pollak NM, Eder S, Rechberger GN, Radner FP, Woelkart G, Kolb D, Schmidt A, Kumari M, Preiss-Landl K, Pieske B, Mayer B, Zimmermann R, Lass A, Zechner R, Haemmerle G. . 2013. Functional cardiac lipolysis in mice critically depends on comparative gene identification-58. J Biol Chem, 288(14):9892-9904. (4.773)

Pollak NM, Schweiger M, Jaeger D, Kolb D, Kumari M, Schreiber R, Kolleritsch S, Markolin P, Grabner GF, Heier C, Zierler KA, Rülicke T, Zimmermann R, Lass A, Zechner R, Haemmerle G. 2013. Cardiac-specific overexpression of perilipin 5 provokes severe cardiac steatosis via the formation of a lipolytic barrier. J Lipid Res, 54(4):1092-1102. (5.559)

van de Weijer T, Havekes B, Bilet L, Hoeks J, Sparks L, Bosma M, Paglialunga S, Jorgensen J, Janssen MC, Schaart G, Sauerwein H, Smeets JL, Wildberger J, Zechner R, Schrauwen-Hinderling VB, Hesselink MK, Schrauwen P. 2013. Effects of Bezafibrate Treatment in a Patient and a Carrier With Mutations in the PNPLA2 Gene, Causing Neutral Lipid Storage Disease With Myopathy. Circ Res, 112:e51-54. (11.861)

Nikam A, Patankar JV, Lackner C, Schöck E, Kratky D, Zatloukal K, Abuja PM. 2013. Transition between acute and chronic hepatotoxicity in mice is associated with impaired energy metabolism and induction of mitochondrial heme oxygenase-1. PLoS One, 8(6):e66094. (3.730)

Doddapattar P, Radovic B, Patankar JV, Obrowsky S, Jandl K, Nusshold C, Kolb D, Vujic N, Doshi L, Chandak PG, Goeritzer M, Ahammer H, Hoefler G, Sattler W, Kratky D. 2013. Xanthohumol ameliorates atherosclerotic plaque formation, hypercholesterolemia, and hepatic steatosis in ApoE-deficient mice. Mol Nutr Food Res, 57(10):1718-1028. (4.310)

Patankar JV, Sachdev V, Obrowsky S, Levak-Frank S, Kratky D. 2013. Intestinal GATA4 deficiency induces proximal fibroblast growth factor 15 expression and represses hepatic gluconeogenesis. J Hepatol, 59(5):1147-1149. (9.858)

Obrowsky S, Chandak PG, Patankar JV, Povoden S, Schlager S, Kershaw EE, Bogner-Strauss JG, Hoefler G, Levak-Frank S, Kratky D. 2013. Adipose triglyceride lipase is a TG hydrolase of the small intestine and regulates intestinal PPARalpha signaling. J Lipid Res, 54(2):425-435. (4.386)

Guerfal M, Claes K, Knittelfelder O, De Rycke R, Kohlwein SD, Callewaert N. 2013. Enhanced membrane protein expression by engineering increased intracellular membrane production. Microb Cell Fact, 12:122. (3.306)

Radulovic M, Knittelfelder O, Cristobal-Sarramian A, Kolb D, Wolinski H, Kohlwein SD. 2013. The emergence of lipid droplets in yeast: current status and experimental approaches. Curr Genet, 59(4):231-242. (2.410)

Walenta E, Pessentheiner AR, Pelzmann HJ, Deutsch A, Goeritzer M, Kratky D, Hackl H, Oh DY, Prokesch A, Bogner-Strauss JG. 2013. α/β-Hydrolase Domain Containing Protein 15 (ABHD15) – an Adipogenic Protein Protecting from Apoptosis. PLoS One, 8(11):e79134. (3.730)

Nusshold C, Uellen A, Bernhart E, Hammer A, Damm S, Wintersperger A, Reicher H, Hermetter A, Malle E, Sattler W. 2013. Endocytosis and intracellular processing of BODIPY-sphingomyelin by murine CATH.a neurons. Biochim Biophys Acta, 831(12):1665-1678. (5.538)

Lu J, Roth RA, Malle E, Ganey PE. 2013. Roles of the hemostatic system and neutrophils in liver injury from co-exposure to amiodarone and lipopolysaccharide. Toxicol Sci, 136(1):51-62. (4.328)

Ullen A, Singewald E, Konya V, Fauler G, Reicher H, Nusshold C, Hammer A, Kratky D, Heinemann A, Holzer P, Malle E, Sattler W. 2013. Myeloperoxidase-derived oxidants induce blood-brain barrier dysfunction in vitro and in vivo. PLoS One, 8(5):e64034. (3.730)

Huang J, Das SK, Jha P, Al Zoughbi W, Schauer S, Claudel T, Sexl V, Vesely P, Birner-Gruenberger R, Kratky D, Trauner M, Hoefler G. 2013. The PPARα agonist fenofibrate suppresses B-cell lymphoma in mice by modulating lipid metabolism. Biochim Biophys Acta, 1831(10):1555-1565. (5.538)

Waltl S, Patankar JV, Fauler G, Nusshold C, Ullen A, Eibinger G, Wintersperger A, Kratky D, Malle E, Sattler W. 2013. 25-Hydroxycholesterol regulates cholesterol homeostasis in the murine CATH.a neuronal cell line. Neurosci Lett, 539:16-21. (2.105)

Natter K., Kohlwein SD. 2013. Yeast and cancer cells - common principles in lipid metabolism. Biochim Biophys Acta, 1831(2):314-326. (5.538)

Kohlwein SD, Veenhuis M, van der Klei IJ. 2013. Lipid Droplets and Peroxisomes: Key Players in Cellular Lipid Homeostasis or A Matter of Fat--Store 'em Up or Burn 'em Down. Genetics, 193(1):1-50. (4.389)

Eibinger G, Fauler G, Bernhart E, Frank S, Hammer A, Wintersperger A, Eder H, Heinemann A, Mischel PS, Malle E, Sattler W. 2013. On the role of 25-hydroxycholesterol synthesis by glioblastoma cell lines. Implications for chemotactic monocyte recruitment. Exp Cell Res, 319(12):1828-1838. (3.580)

Bernhart E, Damm S, Wintersperger A, Devaney T, Zimmer A, Raynham T, Ireson C, Sattler W. 2013. Protein kinase D2 regulates migration and invasion of U87MG glioblastoma cells in vitro. Exp Cell Res, 319(13):2037-2048. (3.580)

Konya V, Ullen A, Kampitsch N, Theiler A, Philipose S, Parzmair GP, Marsche G, Peskar BA, Schuligoi R, Sattler W, Heinemann A. 2013. Endothelial E-type prostanoid 4 receptors promote barrier function and inhibit neutrophil trafficking. J Allergy Clin Immuno, 131(2):532-540. (11.003)

Carmona-Gutiérrez D, Alavian-Ghavanini A, Habernig L, Bauer MA, Hammer A, Rossmann C, Zimmermann AS, Ruckenstuhl C, Büttner S, Eisenberg T, Sattler W, Malle E, Madeo F. 2013. The cell death protease Kex1p is essential for hypochlorite-induced apoptosis in yeast. Cell Cycle, 12(11):1704-1712. (5.243)

Marzioni M, Saccomanno S, Agostinelli L, Rychlicki C, Minicis SD, Pierantonelli I, Trauner M, Fickert P, Müller T, Shanmukhappa K, Trozzi L, Candelaresi C, Baroni GS, Benedetti A. 2013. PDX-1/Hes-1 interactions determine cholangiocyte proliferative response to injury in rodents: Possible implications for sclerosing cholangitis. J Hepatol, 58(4):750-756. (9.264)

Büttner S, Faes L, Reichelt WN, Broeskamp F, Habernig L, Benke S, Kourtis N, Ruli D, Carmona-Gutierrez D, Eisenberg T, D'hooge P, Ghillebert R, Franssens V, Harger A, Pieber TR, Freudenberger P, Kroemer G, Sigrist SJ, Winderickx J, Callewaert G, Tavernarakis N, Madeo F. 2013. The Ca2+/Mn2+ ion-pump PMR1 links elevation of cytosolic Ca(2+) levels to α-synuclein toxicity in Parkinson's disease models. Cell Death Differ, 20(3):465-477. (8.371)

Büttner S, Habernig L, Broeskamp F, Ruli D, Vögtle FN, Vlachos M, Macchi F, Küttner V, Carmona-Gutierrez D, Eisenberg T, Ring J, Markaki M, Taskin AA, Benke S, Ruckenstuhl C, Braun R, Van den Haute C, Bammens T, van der Perren A, Fröhlich KU, Winderickx J, Kroemer G, Baekelandt V, Tavernarakis N, Kovacs GG, Dengjel J, Meisinger C, Sigrist SJ, Madeo F. 2013. Endonuclease G mediates α-synuclein cytotoxicity during Parkinson's disease. EMBO J, 32(23):3041-3054. (9.822)

Gupta VK, Scheunemann L, Eisenberg T, Mertel S, Bhukel A, Koemans TS, Kramer JM, Liu KS, Schroeder S, Stunnenberg HG, Sinner F, Magnes C, Pieber TR, Dipt S, Fiala A, Schenck A, Schwaerzel M, Madeo F, Sigrist SJ. 2013. Restoring polyamines protects from age-induced memory impairment in an autophagy-dependent manner. Nat Neurosci, 16(10):1453-1460.

Senovilla L, Vitale I, Martins I, Tailler M, Pailleret C, Michaud M, Galluzzi L, Adjemian S, Kepp O, Niso-Santano M, Shen S, Mariño G, Criollo A, Boileve A, Job B, Ladoire S, Ghiringhelli F, Sistigu A, Yamazaki T, Rello-Varona S, Locher C, Poirier-Colame V, Talbot M, Valent A, Berardinelli F, Antoccia A, Ciccosanti F, Fimia GM, Piacentini M, Fueyo A, Messina NL, Li M, Chan CJ, Sigl V, Pourcher G, Ruckenstuhl C, Carmona-Gutierrez D, Lazar V, Penninger JM, Madeo F, Lopez-Otin C, Smyth MJ, Zitvogel L, Castedo M, Kroemer G. 2013. An immunosurveillance mechanism controls cancer cell ploidy. Science, 337(6102):1678-1684. (31.027)

Fuchs C, Claudel T, Trauner M. 2013. Bile acid-mediated control of liver triglycerides. Semin Liver Dis, 33(4):330-342. Review. (8.274)

Halilbasic E, Baghdasaryan A, Trauner M. 2013. Nuclear receptors as drug targets in cholestatic liver diseases. Clin Liver Dis, 17(2):161-189. Review (2.822)

Claudel T, Trauner M. 2013. Adiponectin, bile acids, and burnt-out nonalcoholic steatohepatitis: new light on an old paradox. Hepatology, 57(6):2106-2109. Review. (12.003)

Jha P, Claudel T, Baghdasaryan A, Mueller M, Halilbasic E, Das SK, Lass A, Zimmermann R, Zechner R, Hoefler G, Trauner M. 2013. Role of adipose triglyceride lipase (PNPLA2) in protection from hepatic inflammation in mouse models of steatohepatitis and endotoxemia. Hepatology, 59(3):858-869. (12.003)

Kollmann K, Heller G, Schneckenleithner C, Warsch W, Scheicher R, Ott RG, Schäfer M, Fajmann S, Schlederer M, Schiefer AI, Reichart U, Mayerhofer M, Hoeller C, Zöchbauer-Müller S, Kerjaschki D, Bock C, Kenner L, Hoefler G, Freissmuth M, Green AR, Moriggl R, Busslinger M, Malumbres M, Sexl V. 2013. A kinase-independent function of CDK6 links the cell cycle to tumor angiogenesis. Cancer Cell, 24(2):167-181. (24.755)

Das SK, Hoefer G. 2013. The role of triglyceride lipases in cancer associated cachexia. Trends Mol Med, 19(5):292-301. (10.355)

Bieghs V, Walenbergh SM, Hendrikx T, van Gorp PJ, Verheyen F, Olde Damink SW, Masclee AA, Koek GH, Hofker MH, Binder CJ, Shiri-Sverdlov R. 2013. Trapping of oxidized LDL in lysosomes of Kupffer cells is a trigger for hepatic inflammation. Liver Int, 33(7):1056-1061. (3.870)

Hendrikx T, Bieghs V, Walenbergh SM, van Gorp PJ, Verheyen F, Jeurissen ML, Steinbusch MM, Vaes N, Binder CJ, Koek GH, Stienstra R, Netea MG, Hofker MH, Shiri-Sverdlov R. 2013. Macrophage Specific Caspase-1/11 Deficiency Protects against Cholesterol Crystallization and Hepatic Inflammation in Hyperlipidemic Mice. PLoS One, 8(12):e78792. (3.730)

Matt U, Sharif O, Martins R, Furtner T, Langeberg L, Gawish R, Elbau I, Zivkovic A, Lakovits K, Oskolkova O, Doninger B, Vychytil A, Perkmann T, Schabbauer G, Binder CJ, Bochkov VN, Scott JD, Knapp S. 2013. WAVE1 mediates suppression of phagocytosis by phospholipid-derived DAMPs. J Clin Invest, 123(7):3014-3024. (12.812)

Montano EN, Boullier A, Almazan F, Binder CJ, Witztum JL, Hartvigsen K. 2013. Development and application of a nonradioactive binding assay of oxidized low-density lipoprotein to macrophage scavenger receptors. J Lipid Res, 54(11):3206-3014. (4.386)

Que X, Widhopf GF 2nd, Amir S, Hartvigsen K, Hansen LF, Woelkers D, Tsimikas S, Binder CJ, Kipps TJ, Witztum JL. 2013. IGHV1-69-encoded antibodies expressed in chronic lymphocytic leukemia react with malondialdehyde-acetaldehyde adduct, an immunodominant oxidation-specific epitope. PLoS One, 8(6):e65203. (3.730)

 

Publications 2012

Eichmann TO, Kumari M, Haas JT, Farese RV Jr, Zimmermann R, Lass A, Zechner R. 2012. Studies on the substrate and stereo/regioselectivity of adipose triglyceride lipase, hormone-sensitive lipase, and diacylglycerol-O-acyltransferases. J Biol Chem, 287(49):41446-57. (4.651)

Morak M, Schmidinger H, Riesenhuber G, Rechberger GN, Kollroser M, Haemmerle G, Zechner R, Kronenberg F, Hermetter A. 2012. Adipose Triglyceride Lipase (ATGL) and Hormone-Sensitive Lipase (HSL) Deficiencies Affect Expression of Lipolytic Activities in Mouse Adipose Tissues. Mol Cell Proteomics, 11(12):1777-1789. (7.251)

Chitraju C, Trotzmuller M, Hartler J, Wolinski H, Thallinger GG, Lass A, Zechner R, Zimmermann, R, Kofeler HC, Spener F.2012. Lipidomic analysis of lipid droplets from murine hepatocytes reveals distinct signatures for nutritional stress. J Lipid Res, 53(10):2141-21452. (4.651)

Schweiger M, Paar M, Eder C, Brandis J, Moser E, Gorkiewicz G, Grond S, Radner FP, Cerk I, Cornaciu I, Oberer M, Kersten S, Zechner R, Zimmermann R, Lass A. 2012. G0/G1 switch gene-2 regulates human adipocyte lipolysis by affecting activity and localization of adipose triglyceride lipase. J Lipid Res, 53(11):2307-2317. (4.386)

Kumari M, Schoiswohl G, Chitraju C, Paar M, Cornaciu I, Ranrez AY, Wongsiriroj N, Nagy HM, Ivanova PT, Scott SA, Knittelfelder O, Rechberger GN, Birner-Gruenberger R, Eder S, Brown HA, Haemmerle G, Oberer M, Lass A, Kershaw EE, Zimmermann R, Zechner R. 2012. Adiponutrin Functions as a Nutritionally Regulated Lysophosphatidic Acid Acyltransferase. Cell Metab, 15(5):691-702. (14.619)

Lasa A, Schweiger M, Kotzbeck P, Churruca I, Simon E, Zechner R, Portillo MD. 2012. Resveratrol regulates lipolysis via adipose triglyceride lipase. J Nutr Biochem, 23(4):379-384. (4.552)

Zechner R, Zimmermann R, Eichmann TO, Kohlwein SD, Haemmerle G, Lass A, Madeo F. 2012. FAT SIGNALS – Lipases and Lipolysis in Lipid Metabolism and Signaling. Cell Metab, 15(3):279-291. (14.619)

Kienesberger PC, Pulinilkunnil T, Sung MM, Nagendran J, Haemmerle G, Kershaw EE, Young ME, Light PE, Oudit GY, Zechner R, Dyck JR. 2012. Myocardial ATGL Over-expression Decreases the Reliance on Fatty Acid Oxidation and Protects Against Pressure Overload-Induced Cardiac Dysfunction. Mol Cell Biol, 32(4):740-750. (5.372)

Grall A, Guaguere E, Planchais S, Grond S, Bourrat E, Hausser I, Hitte C, Le Gallo M, Derbois C, Kim GJ, Lagoutte L, Degorce-Rubiales F, Radner FP, Thomas A, Küry S, Bensignor E, Fontaine J, Pin D, Zimmermann R, Zechner R, Lathrop M, Galibert F, Andre C, Fischer J. 2012. PNPLA1 mutations cause autosomal recessive congenital ichthyosis in golden retriever dogs and humans. Nat Genet, 44(2):140-147. doi: 10.1038/ng. 1056. (35.209)

Schreiber R, Taschler U, Preiss-Landl K, Wongsiriroj N, Zimmermann R, Lass A. 2012. Retinyl ester hydrolases and their roles in vitamin A homeostasis (Review). Biochim Biophys Acta, 1821(1):113-123. (5.538)

Wolinski H, Bredies K, Kohlwein SD. 2012. Quantitative imaging of lipid metabolism in yeast: from 4D analysis to high content screens of mutant libraries. Methods Cell Biol, 108:345-365. (1.444)

Wölkart G, Schrammel A, Dörffel K, Haemmerle G, Zechner R, Mayer B. 2012. Cardiac dysfunction in adipose triglyceride lipase deficiency: Treatment with a PPARα agonist. Br J Pharmacol, 165(2):380-389. (2.516)

Radovic B, Aflaki E, Kratky D. 2012. Adipose triglyceride lipase in immune response, inflammation, and atherosclerosis. Biol Chem, 393(9):1005-1011. (2.683)

Patankar JV, Obrowsky S, Doddapattar P, Hoefler G, Battle M, Levak-Frank S, Kratky D. 2012. Intestinal GATA4 deficiency protects from diet-induced hepatic steatosis. J Hepatol, 57(5):1061-1068. (9.264)

Obrowsky S, Chandak PG, Patankar JV, Pfeifer T, Povoden S, Schreiber R, Haemmerle G, Levak-Frank S, Kratky D. 2012. Cholesteryl ester accumulation and accelerated cholesterol absorption in intestine-specific hormone sensitive lipase-null mice. Biochim Biophys Acta, 1821(11):1406-1414. (5.538)

Aflaki E, Doddapattar P, Radovic B, Povoden S, Kolb D, Vujic N, Wegscheider M, Koefeler H, Hornemann T, Graier WF, Malli R, Madeo F, Kratky D. 2012. C16 ceramide is crucial for triacylglycerol-induced apoptosis in macrophages. Cell Death Dis, 3:e280. doi: 10.1038/cddis.2012.17. (6.044)

Moustafa T, Fickert P, Magnes C, Guelly C, Thueringer A, Frank S, Kratky D, Sattler W, Reicher H, Sinner F, Gumhold J, Silbert D, Fauler G, Höfler G, Lass A, Zechner R, Trauner M. 2012. Alterations in Lipid Metabolism Mediate Inflammation, Fibrosis, and Proliferation in a Mouse Model of Chronic Cholestatic Liver Injury. Gastroenterology, 142(1):140-151.e12. (12.821)

Schriefl AJ, Wolinski H, Regitnig P, Kohlwein SD, Holzapfel GA. 2012. An automated approach for three-dimensional quantification of fibrillar structures in optically cleared soft biological tissues. J R Soc Interface, 10(80):20120760. (4.907)

Rees MD, Dang L, Thai T, Owen DM, Malle E, Thomas SR. 2012. Targeted subendothelial matrix oxidation by myeloperoxidase triggers myosin II-dependent de-adhesion and alters signaling in endothelial cells. Free Radic Biol Med, 53(12):2344-2356. (5.423)

Mattiazzi M, Sun Y, Wolinski H, Bavdek A, Petan T, Anderluh G, Kohlwein SD, Drubin DG, Krizaj I, Petrovic U. 2012. A neurotoxic phospholipase A2 impairs yeast amphiphysin activity and reduces endocytosis. PLoS One, 7(7):e40931. (3.730)

Hanscho M, Ruckerbauer DE, Chauhan N, Hofbauer HF, Krahulec S, Nidetzky B, Kohlwein SD, Zanghellini J, Natter K. 2012. Nutritional requirements of the BY series of Saccharomyces cerevisiae strains for optimum growth. FEMS Yeast Res, 12(7):796-808. (2.462)

Henry SA, Kohlwein SD, Carman GM. 2012. Metabolism and regulation of glycerolipids in the yeast Saccharomyces cerevisiae. Genetics, 190(2):317-349. (4.389)

Beretta M, Wölkart G, Schernthaner M, Griesberger M, Neubauer R, Schmidt K, Sacherer M, Heinzel FR, Kohlwein SD, Mayer B. 2012. Vascular bioactivation of nitroglycerin is catalyzed by cytosolic aldehyde dehydrogenase-2. Circ Res, 110(3):385-393. (11.861)

Paar M, Jüngst C, Steiner NA, Magnes C, Sinner F, Kolb D, Lass A, Zimmermann R, Zumbusch A, Kohlwein SD, Wolinski H. 2012. Remodeling Of lipid droplets during lipolysis and growth in adipocytes. J Biol Chem, 287(14): 11164-11173. (4.651)

Ullen A, Fauler G, Bernhart E, Nusshold C, Reicher H, Leis HJ, Malle E, Sattler W. 2012. Phloretin ameliorates 2-chlorohexadecanal-mediated brain microvascular endothelial cell dysfunction in vitro. Free Radic Biol Med, 53(9):1770-1781. (5.423)

Damm M, Nusshold C, Cantillo D, Rechberger GN, Gruber K, Sattler W, Kappe CO. 2012. Can electromagnetic fields influence the structure and enzymatic digest of proteins? A critical evaluation of microwave-assisted proteomics protocols. J Proteomics, 75(18):5533-5343. (4.088)

Windischhofer W, Huber E, Rossmann C, Semlitsch M, Kitz K, Rauh A, Devaney T, Leis HJ, Malle E. 2012. LPA-induced suppression of periostin in human osteosarcoma cells is mediated by the LPA(1)/Egr-1 axis. Biochimie, 94(9):1997-2005. (3.142)

Minois N, Carmona-Gutierrez D, Bauer MA, Rockenfeller P, Eisenberg T, Brandhorst S, Sigrist SJ, Kroemer G, Madeo F. 2012. Spermidine promotes stress resistance in Drosophila melanogaster through autophagy-dependent and -independent pathways. Cell Death Dis, 3:e401. (6.044)

Ring J, Sommer C, Carmona-Gutierrez D, Ruckenstuhl C, Eisenberg T, Madeo F. 2012. The metabolism beyond programmed cell death in yeast. Exp Cell Res, 318(11):1193-200. (3.557)

Khan MJ, Rizwan Alam M, Waldeck-Weiermair M, Karsten F, Groschner L, Riederer M, Hallström S, Rockenfeller P, Konya V, Heinemann A, Madeo F, Graier WF, Malli R. 2012. Inhibition of Autophagy Rescues Palmitic Acid-induced Necroptosis of Endothelial Cells. J Biol Chem, 287(25):21110-21120. (4.651)

Marzioni M, Saccomanno S, Agostinelli L, Rychlicki C, Minicis SD, Pierantonelli I, Trauner M, Fickert P, Müller T, Shanmukhappa K, Trozzi L, Candelaresi C, Baroni GS, Benedetti A. 2012. PDX-1/Hes-1 interactions determine cholangiocyte proliferative response to injury in rodents: possible implications for sclerosing cholangitis. J Hepatol, 58(4):750-756. (9.264)

Halilbasic E, Claudel T, Trauner M. 2012. Bile acid transporters and regulatory nuclear receptors in the liver and beyond. J Hepatol, 58(1):155-68. (9.264)

Chennamsetty I, Claudel T, Kostner KM, Trauner M, Kostner GM. 2012. FGF19 Signaling Cascade Suppresses APOA Gene Expression. Thromb Vasc Biol, 32(5):1220-1227. (6.338)

Fuchs CD, Claudel T, Kumari P, Haemmerle G, Pollheimer MJ, Stojakovic T, Scharnagl H, Halilbasic E, Gumhold J, Silbert D, Koefeler H, Trauner M. 2012. Absence of adipose triglyceride lipase protects from hepatic endoplasmic reticulum stress in mice. Hepatology, 56(1):270-280. (12.003)

Österreicher CH, Trauner M. 2012. Animal models of biliary tract injury. Curr Opin Gastroenterol, 28(3):239-243. Review (4.103)

Österreicher CH, Trauner M. 2012. Xenobiotic-induced liver injury and fibrosis. Expert Opin Drug Metab Toxicol, 8(5):571-580. Review (2.944)

Tamilarasan KP, Temmel H, Das SK, Al Zoughbi W, Schauer S, Vesely PW, Hoefler G. 2012. Skeletal muscle damage and impaired regeneration due to LPL-mediated lipotoxicity. Cell Death Dis, 3:e354. (6.044)

Chennamsetty I, Kostner KM, Claudel T, Vinod M, Frank S, Weiss TS, Trauner M, Kostner GM. 2012. Nicotinic acid inhibits hepatic APOA gene expression: studies in humans and in transgenic mice. J Lipid Res, 53(11):2405-2412. (4.386)

Graulich T, Das SK, Krasteva G, Ruppert C, Wessels L, Hoefler G, Muhlfeld C. 2012. Cancer cachexia alters intracellular surfactant metabolism but not total alveolar surface area. Histochem Cell Biol, 138(5):803-813. (2.613)

Laimer D, Dolznig H, Kollmann K, Vesely PW, Schlederer M, Merkel O, Schiefer AI, Hassler MR, Heider S, Amenitsch L, Thallinger C, Staber PB, Simonitsch-Klupp I, Artaker M, Lagger S, Turner SD, Pileri S, Piccaluga PP, Valent P, Messana K, Landra I, Weichhart T, Knapp S, Shehata M, Todaro M, Sexl V, Hofler G, Piva R, Medico E, Ruggeri BA, Cheng M, Eferl R, Egger G, Penninger JM, Jaeger U, Moriggl R, Inghirami G, Kenner L. 2012. PDGFR blockade is a rational and effective therapy for NPM-ALK-driven lymphomas. Nat Med, 18(11):1699-1704. (24.302)

Stemmer U, Dunai ZA, Koller D, Pürstinger G, Zenzmaier E, Deigner HP, Aflaki E, Kratky D, Hermetter A. 2012. Toxicity of oxidized phospholipids in cultured macrophages. Lipids Health Dis, 11(1):110. (2.015)

Stemmer U, Hermetter A. Protein modification by aldehydophospholipids and its functional consequences. 2012. Biochim Biophys Acta, 181(10):2436-2446. (5.538)

Stemmer U, Ramprecht C, Zenzmaier E, Stojcic B, Rechberger G, Kollroser M, Hermetter A. 2012. Uptake and protein targeting of fluorescent oxidized phospholipids in cultured RAW 264.7 macrophages. Biochim Biophys Acta, 1821(4):706-718. (5.538)

Amir S, Hartvigsen K, Gonen A, Leibundgut G, Que X, Jensen-Jarolim E, Wagner O, Tsimikas S, Witztum JL, Binder CJ. 2012. Peptide mimotopes of malondialdehyde epitopes for clinical applications in cardiovascular disease. J Lipid Res, 53(7):1316-1326. (4.386)

Weismann D, Binder CJ. 2012. The innate immune response to products of phospholipid peroxidation. Biochim Biophys Acta, 1818(10):2465-2475. (5.538)

Bieghs V, Verheyen F, van Gorp PJ, Hendrikx T, Wouters K, Lütjohann D, Gijbels MJ, Febbraio M, Binder CJ, Hofker MH, Shiri-Sverdlov R. 2012. Internalization of modified lipids by CD36 and SR-A leads to hepatic inflammation and lysosomal cholesterol storage in Kupffer cells. PLoS One, 7(3):e34378. (3.730)

Cardilo-Reis L, Gruber S, Schreier SM, Drechsler M, Papac-Milicevic N, Weber C, Wagner O, Stangl H, Soehnlein O, Binder CJ. 2012. Interleukin-13 protects from atherosclerosis and modulates plaque composition by skewing the macrophage phenotype. EMBO Mol Med, 4(10):1072-1086. (7.795)

Elsøe S, Ahnström J, Christoffersen C, Hoofnagle AN, Plomgaard P, Heinecke JW, Binder CJ, Björkbacka H, Dahlbäck B, Nielsen LB. 2012. Apolipoprotein M binds oxidized phospholipids and increases the antioxidant effect of HDL. Atherosclerosis, 221(1):91-97. (3.706)

Bieghs V, Van Gorp PJ, Wouters K, Hendrikx T, Gijbels MJ, van Bilsen M, Bakker J, Binder CJ, Lütjohann D, Staels B, Hofker MH, Shiri-Sverdlov R. 2012. LDL receptor knock-out mice are a physiological model particularly vulnerable to study the onset of inflammation in non-alcoholic fatty liver disease. PLoS One, 7(1):e30668. (3.730)

Bieghs V, van Gorp PJ, Walenbergh S, Gijbels MJ, Verheyen F, Buurman WA, Briles DE, Hofker MH, Binder CJ, Shiri-Sverdlov R. 2012. Specific immunization strategies a gainst oxidized LDL: A novel way to reduce non-alcoholic steatohepa titis in mice. Hepatology, 56(3):894-903. (12.003)

Rengachari S, Bezerra GA, Riegler-Berket L, Gruber CC, Sturm C, Taschler U, Boeszoermenyi A, Dreveny I, Zimmermann R, Gruber K, Oberer M. 2012. The structure of monoacylglycerol lipase from Bacillus sp. H257 reveals unexpected conservation of the cap architecture between bacterial and human enzymes. Biochim Biophys Acta, 1821(7):1012-1021. (5.538)

Schmidt JC, Arthanari H, Boeszoermenyi A, Dashkevich NM, Wilson-Kubalek EM, Monnier N, Markus M, Oberer M, Milligan RA, Bathe M, Wagner G, Grishchuk EL, Cheeseman IM. 2012. The kinetochore-bound Ska1 complex tracks depolymerizing microtubules and binds to curved protofilaments. Dev Cell, 23(5):968-980. (12.861)

 

Publications 2011

Impact factor 2011 in parenthesis

Cornaciu I, Boeszoermenyi A, Lindermuth H, Nagy HM, Cerk IK, Ebner C, Salzburger B, Gruber A, Schweiger M, Zechner R, Lass A, Zimmermann R, Oberer M. 2011. The Minimal Domain of Adipose Triglyceride Lipase (ATGL) Ranges until Leucine 254 and Can Be Activated and Inhibited by CGI-58 and G0S2, Respectively. PLoS ONE, 6(10):e26349. (4.092)

Etschmaier K, Becker T, Eichmann TO, Schweinzer C, Scholler M, Tam-Amersdorfer C, Poeckl M, Schuligoi R, Kober A, Chirackal Manavalan AP, Rechberger GN, Streith IE, Zechner R, Zimmermann R, Panzenboeck U. 2011. Adipose triglyceride lipase affects triacylglycerol metabolism at brain barriers. J Neurochem, 119(5):1016-1028. (4.061)

Mueller KM, Kornfeld JW, Friedbichler K, Blaas L, Egger G, Esterbauer H, Hasselblatt P, Schlederer M, Haindl S, Wagner KU, Engblom D, Haemmerle G, Kratky D, Sexl V, Kenner L, Kozlov AV, Terracciano L, Zechner R, Schuetz G, Casanova E, Pospisilik JA, Heim MH, Moriggl R. 2011. Impairment of hepatic growth hormone and glucocorticoid receptor signaling causes steatosis and hepatocellular carcinoma in mice. Hepatology, 54(4):1398-1409. (11.665)

Haemmerle G, Moustafa T, Woelkart G, Büttner S, Schmidt A, van de Weijer T, Hesselink M, Jaeger D, Kienesberger PC, Zierler K, Schreiber R, Eichmann T, Kolb D, Kotzbeck P, Schweiger M, Kumari M, Eder S, Schoiswohl G, Wongsiriroj N, Pollak NM, Radner FP, Preiss-Landl K, Kolbe T, Rülicke T, Pieske B, Trauner M, Lass A, Zimmermann R, Hoefler G, Cinti S, Kershaw EE, Schrauwen P, Madeo F, Mayer B, Zechner R. 2011. ATGL-mediated fat catabolism regulated cardiac mitochondrial function via PPAR-α and PGC. Nat Med, 17(9):1076-1085. (22.462)

Harris CA, Haas JT., Streeper RS, Stone SJ, Kumari M, Yang K, Han X, Brownell N, Gross RW, Zechner R, Farese RV Jr. 2011. DGAT enzymes are required for triacylglycerol synthesis and lipid droplets in adipocytes. J Lipid Res, 52(4):657-667. (5.559)

Radner FP, Grond S, Haemmerle G, Lass A, Zechner R. 2011. Fat in the skin: Triacylglycerol metabolism in keratinocytes and its role in the development of neutral lipid storage disease. Dermatoendocrinol, 3(2):77-83.

Das SK, Eder S, Schauer S, Diwoky C, Temmel H, Guertl B, Gorkiewicz G, Tamilarasan KP, Kumari P, Trauner M, Zimmermann R, Vesely P, Haemmerle G, Zechner R, Hoefler G. 2011. Adipose triglyceride lipase contributes to cancer-associated cachexia. Science, 333(6039):233-238. (31.201)

Oberer M, Boeszoermenyi A, Nagy HM, Zechner R. 2011. Recent insights into the structure and function of comparative gene identification-58. Curr Opin Lipidol, 22(3):149-158. (6.086)

Borg ML, Andrews ZB, Duh EJ, Zechner R, Meikle PJ, Watt MJ. 2011. Pigment epithelium-derived factor regulates lipid metabolism via adipose triglyceride lipase. Diabetes, 60(5):1458-1466. (8.286)

Taschler U, Radner FP, Heier C, Schreiber R, Schweiger M, Schoiswohl G, Preiss-Landl K, Jaeger D, Reiter B, Koefeler HC, Wojciechowski J, Theussl C, Penninger JM, Lass A, Haemmerle G, Zechner R and Zimmermann R. 2011. Monoglyceride lipase deficiency in mice impairs lipolysis and attenuates diet-induced insulin resistance. J Biol Chem, 286(20):17467-17477. (4.773)

Aflaki E, Radovic B, Chandak PG, Kolb D, Eisenberg T, Ring J, Fertschai I, Uellen A, Wolinski H, Kohlwein SD, Zechner R, Levak-Frank S, Sattler W, Graier WF, Malli R, Madeo F, Kratky D. 2011. Triacylglycerol accumulation activates the mitochondrial apoptosis pathway in macrophages. J Biol Chem, 286(9):7418-7428. (4.773)

Lass A, Zimmermann R, Oberer M, Zechner R. 2011. Lipolysis - a highly regulated multi-enzyme complex mediates the catabolism of cellular fat stores. Prog Lip Res, 50(1):14-27. (10-667)

Basantani MK, Sitnick MT, Cai L, Brenner DS, Gardner NP, Li JZ, Schoiswohl G, Yang K, Kumari M, Gross RW, Zechner R, Kershaw EE. 2011. Pnpla3/Adiponutrin deficiency in mice does not contribute to fatty liver disease or metabolic syndrome. J Lipid Res, 52(2):318-329. (5.559)

Lammers B, Chandak PG, Aflaki E, Van Puijvelde GH, Radovic B, Hildebrand RB, Meurs I, Out R, Kuiper J, Van Berkel TJ, Kolb D, Haemmerle G, Zechner R, Levak-Frank S, Van Eck M, Kratky D. 2011. Macrophage adipose triglyceride lipase deficiency attenuates atherosclerotic lesion development in low-density lipoprotein receptor knockout mice. Arterioscler Thromb Vasc Biol, 31(1):67-73. (6.368)

Coassin S, Schweiger M, Kloss-Brandstätter A, Lamina C, Haun M, Erhart G, Paulweber B, Rahman Y, Olpin S, Wolinski H, Cornaciu I, Zechner R, Zimmermann R, Kronenberg F. 2010. Investigation and functional characterization of rare genetic variants in the adipose triglyceride lipase in a large healthy working population. PLoS Genet, 6(12):e1001239. (8.694)

Aflaki E, Balenga NA, Luschnig-Schratl P, Wolinski H, Povoden S, Chandak PG, Bogner-Strauss JG, Eder S, Konya V, Kohlwein SD, Heinemann A, Kratky D. 2011. Impaired Rho GTPase activation abrogates cell polarization and migration in macrophages with defective lipolysis. Cell Mol Life Sci, 68(23):3933-3947. (6.570)

Grunert T, Leitner NR, Marchetti-Deschmann M, Miller I, Wallner B, Radwan M, Vogl C, Kolbe T, Kratky D, Gemeiner M, Allmaier G, Müller M, Strobl B. 2011. A comparative proteome analysis links tyrosine kinase 2 (Tyk2) to the regulation of cellular glucose and lipid metabolism in response to poly(I:C). J Proteomics, 74(12):2866-2880 (4.878)

Chandak PG, Obrowsky S, Radovic B, Doddapattar P, Aflaki E, Kratzer A, Doshi LS, Povoden S, Ahammer H, Hoefler G, Levak-Frank S, Kratky D. 2011. Lack of acyl-CoA:diacylglycerol acyltransferase 1 reduces intestinal cholesterol absorption and attenuates atherosclerosis in apolipoprotein E knockout mice. Biochim Biophys Acta, 1811(12):1011-1020. (5.000)

Chennamsetty I, Claudel T, Kostner KM, Baghdasaryan A, Kratky D, Levak-Frank S, Frank S, Gonzalez FJ, Trauner M, Kostner GM. 2011. Farnesoid X receptor represses hepatic human APOA gene expression. J Clin Invest, 121(9):3724-3734. (13.069)

Kratky D. 2011. Neutral cholesterol ester hydrolases in macrophages: still a matter of debate. Circ Res, 108(10):e13. (9.489)

Patankar JV, Chandak PG, Obrowsky S, Pfeifer T, Diwoky C, Uellen A, Sattler W, Stollberger R, Hoefler G, Heinemann A, Battle M, Duncan S, Kratky D, Levak-Frank S. 2011. Loss of intestinal GATA4 prevents diet-induced obesity and promotes insulin sensitivity in mice. Am J Physiol Endocrinol Metab, 300(3):E478-488. (4.746)

Schweinzer C, Kober A, Lang I, Etschmaier K, Scholler M, Kresse A, Sattler W, Panzenboeck U. 2011. Processing of endogenous AbetaPP in blood-brain barrier endothelial cells is modulated by liver-X receptor agonists and altered cellular cholesterol homeostasis. J Alzheimers Dis, 27(2):341-360. (3.745)

Pfeifer T, Buchebner M, Chandak PG, Patankar J, Kratzer A, Obrowsky S, Rechberger GN, Kadam RS, Kompella UB, Kostner GM, Kratky D, Levak-Frank S. 2011. Synthetic LXR agonist suppresses endogenous cholesterol biosynthesis and efficiently lowers plasma cholesterol. Curr Pharm Biotechnol, 12(2):285-292. (2.805)

Wolinski H, Kolb D, Hermann S, Koning RI, Kohlwein SD. 2011. A role for seipin in lipid droplet dynamics and inheritance in yeast. J Cell Sci, 124(Pt 22):3894-3904 (6.111)

Gaspar ML, Hofbauer HF, Kohlwein SD,Henry SA. 2011. Coordination of storage lipid synthesis and membrane biogenesis: evidence for cross-talk between triacylglycerol metabolism and phosphatidylinositol synthesis. J Biol Chem, 286(3):1696-1708. (4.773)

Resch U, Semlitsch M, Hammer A, Susani-Etzerodt H, Walczak H, Sattler W, Malle E. 2011. Hypochlorite-modified low-density lipoprotein induces the apoptotic machinery in Jurkat T-cell lines. Biochem Biophys Res Commun, 410(4):895-900. (2.484)

Semlitsch M, Shackelford RE, Zirkl S, Sattler W, Malle E. 2011. ATM protects against oxidative stress induced by oxidized low-density lipoprotein. DNA Repair (Amst), 10(8):848-860. (4.135)

Hörl G, Wagner A, Cole LK, Malli R, Reicher H, Kotzbeck P, Köfeler H, Höfler G, Frank S, Bogner-Strauss JG, Sattler W, Vance DE, Steyrer E. 2011. Sequential synthesis and methylation of phosphatidylethanolamine promote lipid droplet biosynthesis and stability in tissue culture and in vivo. J Biol Chem, 286(19):17338-17350. (4.773)

Rossmann C, Rauh A, Hammer A, Windischhofer W, Zirkl S, Sattler W, Malle E. 2011. Hypochlorite-modified high-density lipoprotein promotes induction of HO-1 in endothelial cells via activation of p42/44 MAPK and zinc finger transcription factor Egr-1. Arch Biochem Biophys, 509(1):16-25. (2.935)

Penz-Österreicher M, Österreicher CH, Trauner M. 2011. Fibrosis in autoimmune and cholestatic liver disease. Best Pract Res Clin Gastroenterol, 25(2):245-258. (2.456)

Trauner M, Halilbasic E. 2011. Nuclear receptors as new perspective for the management of liver diseases. Gastroenterology, 140(4):1120-1125.e1-12. (11.675)

Wagner M, Zollner G , Trauner M. 2011. Nuclear receptors in liver disease. Hepatology, 53(3):1023-1034. (11.665)

Claudel T, Zollner G, Wagner M, Trauner M. 2011. Role of nuclear receptors for bile acid metabolism, bile secretion, cholestasis, and gallstone disease. Biochim Biophys Acta, 1812(8):867-878. (5.000)

Trauner M, Baghdasaryan A, Claudel T, Fickert P, Halilbasic E, Moustafa T, Zollner G. 2011. Targeting nuclear bile acid receptors for liver disease. Dig Dis, 29(1):98-102. Review. (2.273)

Carmona-Gutiérrez D, Bauer MA, Ring J, Knauer H, Eisenberg T, Büttner S, Ruckenstuhl C, Reisenbichler A, Magnes C, Rechberger GN, Birner-Gruenberger R, Jungwirth H, Fröhlich KU, Sinner F, Kroemer G, Madeo F. 2011. The propeptide of yeast cathepsin D inhibits programmed necrosis. Cell Death Dis, 2:e161. (5.333)

Büttner S, Ruli D, Vögtle FN, Galluzzi L, Moitzi B, Eisenberg T, Kepp O, Habernig L, Carmona-Gutierrez D, Rockenfeller P, Laun P, Breitenbach M, Khoury C, Fröhlich KU, Rechberger G, Meisinger C, Kroemer G, Madeo F. 2011. A yeast BH3-only protein mediates the mitochondrial pathway of apoptosis. EMBO J 30(14):2779-2792. (9.205)

Swinnen E, Büttner S, Outeiro TF, Galas MC, Madeo F, Winderickx J, Franssens V. 2011. Aggresome formation and segregation of inclusions influence toxicity of a-synuclein and synphilin-1 in yeast. Biochem Soc Trans, 39(5):1476-1481. (3.711)

Minois N, Carmona-Gutierrez D, Madeo F. 2011. Polyamines in aging and disease. Aging (Albany NY), 3(8):716-732. (5.127)

Braun RJ, Sommer C, Carmona-Gutierrez D, Khoury CM, Ring J, Büttner S, Madeo F. 2011. Neurotoxic 43-kDa TAR DNA-binding protein (TDP-43) triggers mitochondrion-dependent programmed cell death in yeast. J Biol Chem, 286(22):19958-19972. (4.773)

Marino G, Morselli E, Bennetzen MV, Eisenberg T, Megalou E, Schroeder S, Cabrera S, Benit P, Rustin P, Criollo A, Kepp O, Galluzzi L, Shen S, Malik SA, Maiuri MC, Horio Y, Lopez-Otin C, Andersen JS, Tavernarakis N, Madeo F, Kroemer G. 2011. Longevity-relevant regulation of autophagy at the level of the acetylproteome. Autophagy, 7(6):647-679. (7.453)

Morselli E, Marino G, Bennetzen MV, Eisenberg T, Megalou E, Schroeder S, Cabrera S, Benit P, Rustin P, Criollo A, Kepp O, Galluzzi L, Shen S, Malik SA, Maiuri MC, Horio Y, Lopez-Otin C, Andersen JS, Tavernarakis N, Madeo F, Kroemer G. 2011. Spermidine and resveratrol induce autophagy by distinct pathways converging on the acetylproteome. J Cell Biol, 192(4):615-629. (10.264)

Pinent M, Prokesch A, Hackl H, Voshol PJ, Klatzer A, Walenta E, Panzenboeck U, Kenner L, Trajanoski Z, Hoefler G, Bogner-Strauss JG. 2011. Adipose triglyceride lipase and hormone-sensitive lipase are involved in fat loss in JunB-deficient mice. Endocrinology, 152(7):2678-2689. (4.459)

Weismann D, Hartvigsen K, Lauer N, Bennett KL, Scholl HP, Charbel Issa P, Cano M, Brandstätter H, Tsimikas S, Skerka C, Superti-Furga G, Handa JT, Zipfel PF, Witztum JL, Binder CJ. 2011. Complement factor H binds malondialdehyde epitopes and protects from oxidative stress. Nature, 478(7367):76-81. (36.280)



Publications 2010

Impact factor 2010 in parenthesis

Coassin S, Schweiger M, Kloss-Brandstätter A, Lamina C, Haun M, Erhart G, Paulweber B, Rahman Y, Olpin S, Wolinski H, Cornaciu I, Zechner R, Zimmermann R and Kronenberg F. 2010. Investigation and functional characterization of rare genetic variants in the adipose triglyceride lipase in a large healthy working population. PLoS Genet, 6(12):e1001239. (9.543)

Chandak PG, Radovic B, Aflaki E, Kolb D, Buchebner M, Fröhlich E, Magnes C, Sinner F, Haemmerle G, Zechner R, Tabas I, Levak-Frank S and Kratky D. 2010. Efficient phagocytosis requires triacylglycerol hydrolysis by adipose triglyceride lipase. J Biol Chem, 285(26):20192-20201. (5.328)

Radner FP, Streith IE, Schoiswohl G, Schweiger M, Kumari M, Eichmann TO, Rechberger G, Koefeler HC, Eder S, Schauer S, Theussl HC, Preiss-Landl K, Lass A, Zimmermann R, Hoefler G, Zechner R, Haemmerle G. 2010. Growth retardation, impaired triacylglycerol catabolism, hepatic steatosis, and lethal skin barrier defect in mice lacking comparative gene identification-58 (CGI-58). J Biol Chem, 285(10):7300-11. (5.328)

Schoiswohl G, Schweiger M, Schreiber R, Gorkiewicz G, Preiss-Landl K, Taschler U, Zierler KA, Radner FP, Eichmann TO, Kienesberger PC, Eder S, Lass A, Haemmerle G, Alsted TJ, Kiens B, Hoefler G, Zechner R and Zimmermann R. 2010. Adipose triglyceride lipase plays a key role in the supply of the working muscle with fatty acids. J Lipid Res, 51(3):490-499. (6.115)

Rohde E, Schallmoser K, Reinisch A, Hofmann NA, Pfeifer T, Fröhlich E, Rechberger G, Lanzer G, Linkesch W, Kratky D, Strunk D. 2010. Pro-angiogenic induction of myeloid cells for therapeutic angiogenesis can induce MAPK p38-dependent foam cell formation. Cytotherapy, 13(4:503-512. (2.925)

Zechner R and Madeo F. 2010. Cell biology: Another way to get rid of fat. Nature, 458(7242):1118-1119. Comment. (36.104)


Schmidt K, Martens-Lobenhoffer J, Meinitzer A, Graier WF, Torres CM, Venema RC and Mayer B. 2010. Activation of endothelial nitric oxide synthase by the pro-apoptotic drug embelin: striking discripancy between nitric oxide-mediated cyclic GMP accumulation and L-citrulline formation. Nitric Oxide, 22(4):281-289 (2.997)

Meda C, Plank C, Mykhaylyk O, Schmidt K and Mayer B. 2010. Effects of statins on nitric oxide/cGMP signaling in human umbilical vein endothelial cells. Pharmacological Report, 62(1):100-112 (2.500)

Buchebner M, Pfeifer T, Rathke N, Chandak PG, Lass A, Schreiber R, Kratzer A, Zimmermann R, Sattler W, Koefeler H, Froehlich E, Kostner GM, Birner-Gruenberger R, Chiang KP, Haemmerle G, Zechner R, Levak-Frank S, Cravatt BF and Kratky D. 2010. Cholesteryl ester hydrolase activity is abolished in HSL-/- macrophages but unchanged in macrophages lacking KIAA1363. J Lipid Res, 51(10):2896-2908. (6.115)

Gaspar ML, Hofbauer HF, Kohlwein SD and Henry SA. 2010. Coordination of storage lipid synthesis and membrane biogenesis: evidence for cross-talk between triacylglycerol metabolism and phosphatidylinositol synthesis. J Biol Chem, 286(3):1696-1708. (5.328)

Low KL, Shui G, Natter K, Yeo WK, Kohlwein SD, Dick T, Rao SP and Wenk MR. 2010.
Lipid droplet-associated proteins are involved in the biosynthesis and hydrolysis of triacylglycerol in Mycobacterium bovis bacillus calmette-guerin. J Biol Chem, 285(28):21662-21670. (5.328)

Plochberger B, Stockner T, Chiantia S, Brameshuber M, Weghuber J, Hermetter A, Schwille P and Schütz GJ. 2010. Cholesterol Slows down the Lateral Mobility of an Oxidized Phospholipid in a Supported Lipid Bilayer. Langmuir, 26(22):17322-17329. (4.269)

Stojakovic T, Claudel T, Putz-Bankuti C, Fauler G, Scharnagl H, Wagner M,Sourij H, Stauber RE, Winkler K, März W, Wascher TC and Trauner M. 2010. Low-dose atorvastatin improves dyslipidemia and vascular function in patients with primary biliary cirrhosis after one year of treatment. Atherosclerosis, 209(1):178-183. (4.086)

Mlecnik B, Tosolini M, Charoentong P, Kirilovsky A, Bindea G, Berger A, Camus M, Gillard M, Bruneval P, Fridman WH, Pages F, Trajanoski Z and Galon J. 2010. Biomolecular network reconstruction identifies T cell homing factors associated with survival in colorectal cancer. Gastroenterology, 138(4):1429-1440. (12.032)

Mlecnik B, Sanchez-Cabo F, Charoentong P, Bindea G, Pages F, Berger A, Galon J and Trajanoski Z. 2010. Data integration and exploration for the identification of molecular mechanisms in tumor-immune cells interaction. BMC Genomics, 11 Suppl 1:S7. (4.206)

Bogner-Strauss JG, Prokesch A, Sanchez-Cabo F, Rieder D, Hackl H, Duszka K, Krogsdam A, Di Camillo B, Walenta E, Klatzer A, Lass A, Pinent M, Wong WC, Eisenhaber F and Trajanoski Z. 2010. Reconstruction of gene association network reveals a transmembrane protein required for adipogenesis and targeted by PPARg. Cell Mol Life Sci, 67(23):4049-4064. (7.047)

Nusshold C, Kollroser M, Kofeler H, Rechberger G, Reicher H, Ullen A, Bernhart E, Waltl S, Kratzer I, Hermetter A, Hackl H, Trajanoski Z, Hrzenjak A, Malle E and Sattler W. 2010. Hypochlorite modification of sphingomyelin generates chlorinated lipid species that induce apoptosis and proteome alterations in dopaminergic PC12 neurons in vitro. Free Radical Biol Med 48(129:1588-1600. (5.707)

Ullen A, Fauler G, Köfeler H, Waltl S, Nusshold C, Bernhart E, Reicher H, Leis HJ, Wintersperger A, Malle E and Sattler W. 2010. Mouse brain plasmalogens are targets for hypochlorous acid-mediated modification in vitro and in vivo. Free Radical Biol Med, 49(11):1655-1665. (5.707)


Naghdi S, Waldeck-Weiermair M, Fertschai I, Poteser M, Graier WF and Malli R. 2010. Mitochondrial Ca2+ uptake and not mitochondrial motility is required for STIM1/Orai1-dependent store-operated Ca2+ entry. J Cell Sci, 123(Pt 15):2553-2564. (6.290)

Waldeck-Weiermair M, Malli R, Naghdi S,Trenker M, Kahn MJ and Graier WF. 2010. The contribution of UCP2 and UCP3 to mitochondrial Ca2+ uptake is differentially determined by the source of supplied Ca2+. Cell Calcium, 47(5):433-440. (3.553)

Bondarenko A, Waldeck-Weiermair M, Naghdi S, Poteser M, Malli R and Graier WF. 2010. G-protein coupled receptor 55-dependent and -independent ion signaling in response to lysophosphatidylinositol in endothelial cells. Brit J Pharmacol, 161(2):308-320. (4.925)

Thevissen K, Yen WL, Carmona-Gutierrez D, Idkowiak-Baldys J, Aerts AM, Francois IE, Madeo F, Klionsky DJ, Hannun YA and Cammue BP. 2010. Skn1 and ipt1 negatively regulate autophagy in saccharomyces cerevisiae. FEMS Microbiol Lett, 303(3):163-168. (2.040)

Madeo F, Eisenberg T, Buttner S, Ruckenstuhl C and Kroemer G. Spermidine. 2010. A novel autophagy inducer and longevity elixir. Autophagy 6(1):160-162. (6.643)

Rockenfeller P, Ring J, Muschett V, Beranek A, Buettner S, Carmona-Gutierrez D, Eisenberg T, Khoury C, Rechberger G, Kohlwein SD, Kroemer G and Madeo F. 2010. Fatty acids trigger mitochondrion-dependent necrosis. Cell Cycle, 9(14):2836-2842. (4.999)


Kohlwein SD. 2010. Obese and anorexic yeasts: Experimental models to understand the metabolic syndrome and lipotoxicity. Biochim Biophys Acta (Mol Cell Biol L), 1801(3):222-229. Review. (5.084)

Kohlwein SD. 2010. Triacylglycerol homeostasis: insights from yeast. Invited review. J Biol Chem, 285(21):15663-15667. (5.328)

Deng Y, Almsherqi ZA, Ng MM, Kohlwein SD. 2010. Do viruses subvert cholesterol homeostasis to induce host cubic membranes? Trends Cell Biol, 20(7)9:371-379. (12.140)

Trauner M, Claudel T, Fickert P, Moustafa T and Wagner M. 2010. Bile acids as regulators of hepatic lipid and glucose metabolism. Digest Dis, 28(1):220-224. Review. (1.000)

Wagner M, Zollner G and Trauner M. 2010. Nuclear receptor regulation of the adaptive response of bile acid transporters in cholestasis. Semin Liver Dis, 30(2):160-177. Review. (5.286)

Zollner G, Wagner M and Trauner M. 2010. Nuclear receptors as drug targets in cholestasis and drug-induced hepatotoxicity. Pharmacol Therapeut, 126(3):228-243. Review. (8.694)

Karpen SJ and Trauner M. 2010. The new therapeutic frontier - nuclear receptors and the liver. J Hepatol, 52(3):455-462. Conference review. (9.334)

Trauner M, Arrese M and Wagner M. 2010. Fatty liver and lipotoxicity. Biochim Biophys Acta (Mol Cell Biol L), 1801(3):299-310. Review. (5.084)

Malli R and Graier WF. 2010. Mitochondrial Ca2+ Channels: Great Unknowns with Important Functions. FEBS Lett, 584(10):1942-1947. Review. (3.601)

Madeo F, Tavernarakis N and Kroemer G. 2010. Can Autophagy promote longevity? Nat Cell Biol, 12(9):842-846. Review. (19.407)

Lass A, Zimmermann R, Oberer M and Zechner R. 2010. Lipolysis - a highly regulated multi-enzyme complex mediates the catabolism of cellular fat stores. Prog Lipid Res, 50(1):14-27. Review. (9.510)

Carmona-Gutierrez D, Eisenberg T, Büttner S, Meisinger C, Kroemer G and Madeo F. 2010. Apoptosis in yeast: triggers, pathways, subroutines. Cell Death Diff, 15(3):257-268. Review. (9.050)

Carmona-Gutierrez D, Fröhlich KU, Kroemer G and Madeo F. 2010. Metacaspases are caspases. Doubt no more. Cell Death Differ, 17(3):377-378. (9.050)

Ruckenstuhl C, Carmona-Gutierrez D and Madeo F. 2010. The sweet taste of death: glucose triggers apoptosis during yeast chronological aging. Aging (Albany NY), 2(10):643-649. (3.576

Büttner S, Delay C, Franssens V, Bammens T, Ruli D, Zaunschirm S, de Oliveira RM, Outeiro TF, Madeo F, Buee L, Galas MC and Winderickx J. 2010. Synphilin-1 enhances α-synuclein aggregation in yeast and contributes to cellular stress and cell death in a Sir2-dependent manner. PLoS One, 5:e13700. (4.411)

Braun RJ, Buttner S, Ring J, Kroemer G and Madeo F. 2010. Nervous yeast: Modeling neurotoxic cell death. Trends Biochem Sci, 35(3):135-144. (10.364)

Bentley M, Nycz D, Joglekar A, Fertschai I, Malli R, Graier WF and Hay JC. 2010. Vesicular calcium regulates coat retention, fusogenicity and size of pre-golgi intermediates. Molecular Biology of the Cell, 21(6):1033-1046. (5.861)

Malli R and Graier WF. 2010. Mitochondrial Ca2+ Channels: Great Unknowns with Important Functions. FEBS Lett, 584(10):1942-7. (3.601)

Baghdasaryan A, Claudel T, Kosters A, Gumhold J, Silbert D, Fuchsbichler A, Leski K, Fickert P, Karpen SJ and Trauner M. 2010. Curcumin improves sclerosing cholangitis in Mdr2-/- mice by inhibition of cholangiocyte inflammatory response and portal myofibroblast proliferation. Gut, 59(4):521-530. (10.614)

Bernhart E, Kollroser M, Rechberger G, Reicher H, Heinemann A, Schratl P, Hallström S, Wintersperger A, Nusshold C, Devaney T, Zorn-Pauly K, Malli R, Graier W, Malle E and Sattler W. 2010. Lysophosphatidic acid receptor engagement affects the microglial proteome leading to alterations in glycolysis, motility, and cytoskeletal architecture. Proteomics, 10(1):141-158. (4.815)

Rockenfeller P and Madeo F. Ageing and eating. 2010. Biochim Biophys Acta, 1803(4):499-506. (5.084)

Eisenberg T, Carmona-Gutierrez D, Büttner S, Tavernarakis N and Madeo F. 2010. Necrosis in yeast. Apoptosis, 9(14):2836-2842. (4.397)



Publications 2009

Impact factor 2009 in parenthesis


Kratzer A, Buchebner M, Pfeifer T, Becker TM, Uray G, Ebner B, Rathke N, Ahammer H, Trauner M, Hoefler G, Levak-Frank S, Kostner GM, Kratky D. 2009. Synthetic LXR agonist attenuates plaque formation and reduces plasma triglycerides in apoE-deficient mice without inducing liver steatosis. J Lipid Res, 50(2):312-326. (4.409)

Alsted TJ, Nybo L, Schweiger M, Fledelius C, Jacobsen P, Zimmermann R, Zechner R, Kiens B. 2009. Adipose triglyceride lipase in human skeletal muscle is upregulated by exercise training. Am J Physiol Endocrinol Metab, 296(3):E445-53. (3,855)

Kienesberger PC, Lee D, Pulinilkunnil T, Brenner DS, Cai L, Magnes C, Koefeler HC, Streith IE, Rechberger GN, Haemmerle G, Flier JS, Zechner R, Kim YB, Kershaw EE. 2009. Adipose triglyceride lipase deficiency causes tissue-specific changes in insulin signaling. J Biol Chem, 284(44):30218-23029. (5,520)

Riederer M, Erwa W, Zimmermann R, Frank S, Zechner R. 2009. Adipose tissue as a source of nicotinamide N-methyltransferase and homocysteine. Atherosclerosis, 204(2):412-417 (4,601)

Zimmermann R, Lass A, Haemmerle G, Zechner R. 2009. Fate of fat: The role of adipose triglyceride lipase in lipolysis. Biochim Biophys Acta, 1791(6):494-500. Review.

Zechner R, Kienesberger PC, Haemmerle G, Zimmermann R, Lass A. 2009. Adipose triglyceride lipase and the lipolytic catabolism of cellular fat stores. J Lipid Res, 50(1):3-21. Review.

Zechner R, Madeo F. 2009. Cell biology: Another way to get rid of fat. Nature, 458(7242):1118-1119. Review.

Schweiger M, Lass A, Zimmermann R, Eichmann TO, Zechner R. 2009. Neutral lipid storage disease: genetic disorders caused by mutations in adipose triglyceride lipase/PNPLA2 or CGI-58/ABHD5. Am J Physiol Endocrinol Metab, 297(2):E289-E296. Review.

Kienesberger PC, Oberer M, Lass A, Zechner R. 2009. Mammalian patatin domain containing proteins: a family with diverse lipolytic activities involved in multiple biological functions. J Lipid Res, 50 Suppl:S63-68. Review.

Kurat CF, Wolinski H, Petschnigg J, Kaluarachchi S, Andrews B, Natter K, Kohlwein SD. 2009. Cdk1/Cdc28-dependent activation of the major triacylglycerol lipase Tgl4 in yeast links lipolysis to cell cycle progression. Mol Cell, 33:53-63. (12,9030)

Wolinski H, Petrovic U, Mattiazzi M, Petschnigg J, Heise B, Natter K, Kohlwein SD. 2009. Imaging-based live cell yeast screen identifies novel factors involved in peroxisome assembly. J Proteome Res, 8(1):20-27. (5,684)

Mlecnik B, Tosolini M, Charoentong P, Kirilovsky A, Bindea G, Berger A, Camus M, Gillard M, Bruneval P, Fridman WH, Pages F, Trajanoski Z, Galon J. 2009. Biomolecular network reconstruction identifies T cell homing factors associated with survival in colorectal cancer. Gastroenterology, Nov 10. [Epub ahead of print] (12,591)

Rhode S, Grurl R, Brameshuber M, Hermetter A, Schütz GJ. 2009. Plasma membrane fludidity affects transcient immobilization of oxidized phospholipids in endocytotic sites for subsequent uptake. J Biol Chem, 284:22258-65. 85. (5,520)

Prokesch A*, Hackl H*, Hakim-Weber R, Bornstein SR, Trajanoski Z. 2009. Novel insights into adipogenesis from omics data. Curr Med Chem. 16:2952-2964. (5,291)

Aerts AM, Zabrocki P, Govaert G, Mathys J, Carmona-Gutierrez D, Madeo F, Winderick J, Cammue BP, Thevissen K. 2009. Mitochondrial dysfunction leads to reduced chronological lifespan and increased apoptosis in yeast. FEBS Lett, 583(1):113-117. (3,264)

Almsherqi ZA, Landh T, Kohlwein SD, Deng Y. 2009. Cubic Membranes: the Missing Dimension of Cell Membrane Organization. Int Rev Cell Mol Biol, 274:275-342. (invited review)

Beranek A, Rechberger G, Knauer H, Wolinski H, Kohlwein SD, Leber R. 2009. Identification of a cardiolipin-specific phospholipase encoded by the gene CLD1 (YGR110W) in yeast. J Biol Chem, 284(17):11572-11578. (5,520)

Wolinski H, Natter K, Kohlwein SD. The fidgety yeast: focus on high-resolution live yeast cell microscopy. 2009. In Methods in Molecular Biology: Yeast Functional Genomics and Proteomics. I.Stagljar, ed. Humana Press, vol. 548, pp 75-99.

Gürtl B, Kratky D, Guelly C, Zheng L, Gorkiewicz G, Suman KD, Tamilarasan KP, Hoefler G. 2009. Apoptosis and fibrosis are early features of heart failure in an animal model of metabolic cardiomyopathy. Int J Exp Pat, 90(3):338-346.

Graier W, Malli R, Kostner GM. 2009. Mitochondrial protein phosphorylation: Instigator or target of lipotoxicity? Review. Trends Endocrinol Metab, 20(4):186-193.

Kratzer I, Bernhart E, Wintersperger A, Hammer A, Waltl S, Malle E, Sperk G, Wietzorrek G, Dieplinger H, Sattler W. 2009. Afamin is synthesized by cerebrovascular endothelial cells and mediates a-tocopherol transport across an in vitro model of the blood-brain barrier. J Neurochem, 108(3):707-18. (4,500)

Chantepie S, Malle E, Sattler W, Chapman JM, Kontush A. 2009. HDL-particle subclasses distinct in physicochemical properties present similar intrinsic susceptibility to oxidative modification by hypochlorous acid. Arch Biochem Biophys, 487(1):28-35. (2,626)

Rees MD, Bottle SE, Fairfull-Smith KE, Malle E, Whitelock JM, Davies MJ. 2009. Inhibition of myeloperoxidase-mediated hypochlorous acid production by nitroxides. Biochem J, 421(1):79-86. (4,371)

Vesely PW, Staber PB, Hoefler G, Kenner L. 2009. Translational regulation mechanisms of AP-1 proteins. Mutat Res, 682(1):7-12. Review.

Petschnigg J, Wolinski H, Kolb D, Zellnig G, Kurat CF, Natter K, Kohlwein SD. 2009. Good fat - essential cellular requirements for triacylglycerol synthesis to maintain membrane homeostasis in yeast. J Biol Chem, 284(45):30981-30993 (5,520)

Aksam EB, Jungwirth H, Kohlwein SD, Ring J, Madeo F, Veenhuis M, van der Klei IJ. 2009. Absence of the peroxiredoxin Pmp20 causes peroxisomal protein leakage and necrotic cell death. Free Radic Biol Med, 45(8):1115-1124. (5,399)

Deng Y, Almsherqi ZA, Shui G, Wenk MR, Kohlwein SD. 2009. Docosapentaenoic acid (DPA) is a critical determinant of cubic membrane formation in amoeba Chaos mitochondria. FASEB J,, 23(9):2866-2871. (7,049)

Madeo F, Carmona-Gutierrez D, Ring J, Büttner S, Eisenberg T, Kroemer G. Caspase-dependent and caspase-independent cell death pathways in yeast. Biochem Biophys Res Commun. 2009, 382(2):227-231. Review.

Claudel T, Trauner M. 2009. Bile acids and their receptors. In: Dufour JF; Clavien PA (eds.) Signaling Pathways in Liver Diseases. Springer Scientific Publishers, 317-332. (ISBN: 978-3-642-00149-9).

Braun RJ, Büttner S, Ring J, Kroemer G, Madeo F. 2009. Nervous yeast: modeling neurotoxic cell death. Trends Biochem Sci, , Nov 17. [Epub ahead of print]

Madeo F, Eisenberg T, Kroemer G. 2009. Autophagy for the avoidance of neurodegeneration. Genes Dev, 23(19):2253-9. (13,623)

Aerts AM, Carmona-Gutierrez D, Lefevre S, Govaert G, François IE, Madeo F, Santos R, Cammue BP, Thevissen K. 2009. The antifungal plant defensin RsAFP2 from radish induces apoptosis in a metacaspase independent way in Candida albicans. FEBS Lett, 583(15):2513-6. (3,264)


Publications 2008

Reid BN, Ables GP, Otlivanchik OA, Schoiswohl G, Zechner R, Blaner WS, Goldberg IJ, Schwabe RF, Chua SC Jr, Huang LS. 2008. Hepatic Overexpression of Hormone-sensitive Lipase and Adipose Triglyceride Lipase Promotes Fatty Acid Oxidation, Stimulates Direct Release of Free Fatty Acids, and Ameliorates Steatosis. J Biol Chem, 283(19):13087-99 (5.520)

Kienesberger PC, Lass A, Preiss-Landl K, Wolinski H, Kohlwein SD, Zimmermann R, Zechner R. 2008. Identification of an insulin-regulated lysophospholipase with homology to neuropathy target esterase. J Biol Chem, 283(9):5908-17 (5.520)

Waldeck-Weiermair M, Zoratti C, Osibow K, Balenga N, Goessnitzer E, Waldhoer M, Malli R, Graier WF. 2008. Integrin clustering enables anandamide-induced Ca2+ signaling in endothelial cells via GPR55 by protection against CB1-receptor-triggered repression. J Cell Sci, 121(10):1704-17 (6.247)

Jousset H, Malli R, Girardin N, Graier WF, Demaurex N, Frieden M. 2008. Evidence for a receptor-activated Ca2+ entry pathway independent from Ca2+ store depletion in endothelial cells. Cell Calcium, 43(1):83-94 (4.481)

Rauh A, Windischhofer W, Kovacevic A, Devaney T, Huber E, Semlitsch M, Leis HJ, Sattler W, Malle E. 2008. Endothelin (ET)-1 and ET-3 promote expression of c-fos and c-jun in human choriocarcinoma via ET(B) receptor-mediated G(i)- and G(q)-pathways and MAP kinase activation. Br J Pharmacol, 154(1):13-24 (4.902)

Kovacevic A, Hammer A, Stadelmeyer E, Windischhofer W, Sundl M, Ray A, Schweighofer N, Friedl G, Windhager R, Sattler W, Malle E. 2008. Expression of serum amyloid A transcripts in human bone tissues, differentiated osteoblast-like stem cells and human osteosarcoma cell lines. J Cell Biochem, 103(3):994-1004 (3.540)

Deigner HP, Hermetter A. 2008. Oxidized phospholipids: emerging lipid mediators in pathophysiology. Curr Opin Lipidol, 19(3):289-94 (6.629)

Rasmussen JA and Hermetter A. 2008. Chemical synthesis of fluorescent glycero- and sphingolipids. Progr Lipid Res, 47(6):436-60. (11.237)

Steiner AJ, Stuetz AE, Wrodnigg TM, Tarling CA, Withers SG, Hermetter A, Schmidinger H. 2008. Glycosidase profiling with immobilised glycosidase-inhibiting iminoalditols - a proof-of-concept study. Bioorg Med Chem Lett, 18:1922-1925 (2.531)

Kohlwein SD. 2008. Von fettleibigen und mageren Hefezellen: mikroskopische Einblicke in den zellulären Fettstoffwechsel. BIOforum 2/2008, 021-023.

Elabd C, Basillais A, Beaupied H, Breuil V, Wagner N, Scheideler M, Zaragosi LE, Massiéra F, Lemichez E, Trajanoski Z, Carle G, Euller-Ziegler L, Ailhaud G, Benhamou CL, Dani C, Amri EZ. 2008. Oxytocin controls differentiation of human mesenchymal stem cells and reverses osteoporosis. Stem Cells, 26(9):2399-2407 (7.741)

Graier WF, Frieden M, Malli R. 2008. Mitochondria and Ca(2+) signaling: old guests, new functions. Pflugers Arch, 455(3):375-96. Review.

Trenker M, Fertschai I, Malli R and Graier WF. 2008. CP2/3 – Likely to be fundamental for mitochondrial Ca2+ uniport. Nat Cell Biol, 10:1237-1240. (14.612)

Graier WF and Hecker M. 2008. Endothelial H2O2: a bad guy turning good? Arteriosler Thromb Vasc Biol, 28:1696-1698 (6.858)

Malli R, Shamim Naghdi S, Romanin C and Graier WF. 2008. Cytosolic Ca2+ prevents the subplasmalemmal clustering of STIM1: an intrinsic mechanism to avoid Ca2+ overload. J Cell Sci, 121:3133-3139 (6.247)

Pinent M, Hackl H, Burkard TR, Prokesch A, Papak C, Scheideler M, Hämmerle G, Zechner R, Trajanoski Z, Strauss JG. 2008. Differential transcriptional modulation of biological processes in adipocyte triglyceride lipase and hormone-sensitive lipase-deficient mice. Genomics, 92(1):26-32. (3.075)

Scheideler M, Elabd C, Zaragosi, LE, Chiellini C, Yadav S, Duszka K, Hackl H, Sanchez-Cabo F, Friedl G, Papak C, Prokesch A, Windhager R, Ailhaud G, Dani C, Amri EZ, Trajanoski Z. 2008. Comparative transciptomics of human multipotent stem cells during adipogenesis and osteoblastogenesis. BMC Genomics, 9:340. (4.128)

Chiellini C, Grenningloh G, Cochet O, Scheideler M, Trajanoski Z, Ailhaud G, Dani C, E-Z Amri. 2008. Stathmin-like 2, a developmentally-associated neuronal marker, is expressed and modulated during osteogenesis of human mesenchymal stem cells. Biochem Biophys Res Commun, 374(1):64-68 (2.648)

Malanovic N, Streith I, Wolinski H, Rechberger GN, Kohlwein SD, Tehlivets O. 2008. Key role of S-adenosyl-L-homocysteine hydrolase in regulating phosphatidylcholine synthesis and triacylglycerol homeostasis in yeast: Implications for homocysteine as a risk factor for lipid-associated disease. J Biol Chem, 283(35):23989-23999 (5.520)

Gaspar ML, Jesch SA, Viswanatha R, Antosh AL, Brown WJ, Kohlwein SD and Henry SA. 2008. A block in ER-to-golgi trafficking inhibits phospholipid synthesis and induces neutral lipid accumulation. J Biol Chem, 283(37):25735-51. (5.520)

Cipak A, Jaganjac M, Tehlivets O, Kohlwein SD, Zarkovic N. 2008. Adaptation to oxidative stress induces by polyunsaturated fatty acids in yeast. Biochim Biophys Acta, 1781(6-7):283-287 (4.564)

Marsche G, Furtmüller PG, Obinger C, Sattler W, Malle E. 2008. Hypochlorite-modified high-density lipoprotein acts as a sink for myeloperoxidase in vitro. Cardiovasc Res, 79(1):187-194 (5.947)

Graier WF, Trenker M, Malli R. 2008. Mitochondrial Ca2+, the secret behind the function of uncoupling proteins 2 and 3? Cell Calcium, 44(1):36-50 (4.481)

Schweiger M, Schoiswohl G, Lass A, Radner FP, Haemmerle G, Malli R, Graier W, Cornaciu I, Oberer M, Salvayre R, Fischer J, Zechner R, Zimmermann R. 2008. The C-terminal region of human adipose triglyceride lipase affects enzyme activity and lipid droplet binding. J Biol Chem, 283(25):17211-17220. (5.520)

Fruhwirth GO, Hermetter A. 2008. Mediation of apoptosis by oxidized phospholipids. In Lipids in Health and Disease, P.J.Quinn, ed., Springer, Subcellular Biochemistry, Vol. 38, 49:351-367

Wolinski H, Kohlwein SD. 2008. Microscopic analysis of lipid droplet metabolism and dynamics in yeast. in Methods in Molecular Biology: Membrane Trafficking. A.Vancura, ed. Humana Press, 457:151-163

Low CP, Shui G, Liew LP, Buttner S, Madeo F, Dawes IW, Wenk MR, Yang H. 2008. Caspase Dependent and Independent Lipotoxic Cell Death Pathways in the Fission Yeast. J Cell Sci, 121(Pt 16):2671-2684 (6.247)

Aerts AM, Zabrocki P, François IE, Carmona-Gutierrez D, Govaert G, Mao C, Smets B, Madeo F, Winderickx J, Cammue BP, Thevissen K. 2008. Ydc1p ceramidase triggers organelle fragmentation, apoptosis and accelerated ageing in yeast. Cell Mol Life Sci, 65(12):1933-1942 (5.457)


Publications 2007

Trenker M, Malli R, Fertschai I, Levak-Frank S, Graier WF. 2007. Uncoupling proteins 2 and 3 are fundamental for mitochondrial Ca2+ uniport. Nat Cell Biol 9(4):445-52 (14.612)

Malle E, Furtmüller PG, Sattler W, Obinger C. 2007. Myeloperoxidase: a target for new drug development? Review. Br J Pharmacol,152(6):838-54.

Marsche G, Weigle B, Sattler W, Malle E. 2007. Soluble RAGE blocks scavenger receptor CD36-mediated uptake of hypochlorite-modified low-density lipoprotein. FASEB J, 21(12):3075-82 (7.049)

Birner-Gruenberger R, Hermetter A. 2007. Activity-based proteomics of lipolytic enzymes. Review. Curr Drug Discov Technol, 4(1):1-11

Moumtzi A, Trenker M, Flicker KH, Zenzmaier E, Saf R and Hermetter A. 2007. Import and fate of fluorescent analogs of oxidized phospholipids in vascular smooth muscle cells. J Lipid Res, 48: 565-582 (6. 247)

Fruhwirth GO, Loidl A, Hermetter A. 2007. Oxidized phospholipids: from molecular properties to disease. Review. Biochim Biophys Acta, 1772(7):718-36. (4.564)

Almeida B, Buttner S, Ohlmeier S, Silva A, Mesquita A, Sampaio-Marques B, Osório NS, Kollau A, Mayer B, Leão C, Laranjinha J, Rodrigues F, Madeo F, Ludovico P. 2007. NO-mediated apoptosis in yeast. J Cell Sci, 120(Pt 18):3279-88 (6. 247)

Kohlwein SD, Petschnigg J. 2007. Lipid-induced Cell Dysfunction and Cell Death: Lessons from Yeast. Curr Hypertens Rep, 9(6):455-461 (1.885)

Panzenboeck U, Andersson U, Hansson M, Sattler W, Meaney S, Björkhem I. 2007. On the mechanism of cerebral accumulation of cholestanol in patients with cerebrotendinous xanthomatosis. J Lipid Res, 48(5):1167-74 (4.409)

Ameida B, Buttner S, Ohlmeier S, Silva A, Mesquita A, Sampaio-Marques B, Osoria NS, Kollau A, Mayer B, Leao C, Laranjinha J, Rodrigues F, Madeo F, Ludovica P. 2007. NO-mediated apoptosis in yeast. J Cell Sci 120:3279-88. (6.247)


For complete publication lists of the consortium members (principle investigators) please refer to their CVs with publication lists:

Zechner
R. Zechner
Haemmerle
G. Haemmerle
Mayer
M. Trauner
Madeo
F. Madeo
Froehlich
KU. Fröhlich
Haemmerle
C. Binder
Trauner
M. Oberer
Sattler
J. Bogner-Strauss


                         

Supported by              
 
   

updated 28.04.2016                                                                                                

SFB LIPOTOX
Project Management: Julia Fröhlich, PhD, University of Graz, Institute of Molecular Biosciences, Heinrichstrasse 31, A-8010 Graz, Austria

julia.froehlich@uni-graz.at

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